Amyloidosis and Alzheimer's disease diagnostic assay and reagent

Details Amyloidosis and Alzheimer's disease diagnostic assay and reagent Amyloidosis and Alzheimer's disease diagnostic assay and reagent

1990-04-17

1991-04-16

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

534860, 534878, 534879, 534881, A61K 4902, C07C24500

Patent

active

050080997

ABSTRACT:
The presence and location of amyloid deposits in an organ or body area of a patient is effected by intravenous administration of novel radioactive iodine-labeled amyloid binding compounds and preferably .sup.123 I-labeled compounds to the patient and sensing radiation emitted from the organ or body area. Novel non-radioactive iodine substituted amyloid binding compounds and amyloid binding compounds which are readily iodinated are further aspects or the invention.

REFERENCES:
patent: 4412951 (1983-11-01), Inagaki et al.
patent: 4666829 (1987-05-01), Glenner et al.
patent: 4853210 (1989-08-01), Kass
patent: 4933156 (1990-06-01), Quay et al.
Suarez et al., Preparation of Congo Red .sup.131 I, (Buenos Aires: Argentinian National Atomic Energy Commission, 1974).
Glenner, New England Journal of Medicine, 302:1283-92, 23, (1980).
Glenner, New England Journal of Medicine, 302:1333-43, 24, (1980).
St. George-Hyslop, Science, 235:885-90, (1987).
Tanzi, Science, 235:880-4, (1987).
Goldgaber, Science, 235:877-80, (1987).
Glenner, Biochemical & Biophysical Communications, 120:885-90, (1984).
Warner, Anal. Chem., 59:1203A-1204A, (1987).
Glenner, Cold Spring Harber Symposium, 1983, pp. 137-144.
Cohen, J. Exp. Med., 158:623-8, (1983).
Puchtler, J. Histochem. Cytochem., 10:355-364, (1962).
Kelenyi, J. Histochem. Cytochem., 15:172-80, (1967).
Puchtler, Histochem., 77:431-45, (1983).
Unger, J. Clin. Invest., 27:111, (1948).
Knorpp, J. Nucl. Med., 1:23-30, (1960).
Tubis, J. Amer. Pharm. Ass., 49:422, (1960).
Tubis, J. Nuklear Medizin, 3:25-38, (1962).
Kaye, Canadian Med. Ass. J., 30:694, (1964).
Zollinger, "Azo and Diazo Chem. Aliphatic and Aromatic Compounds", N.Y. Interscience Publishers, (1961).
Venkataraman, "The Analytical Chemistry of Sythetic Dyes", N.Y., Wiley-Interscience Publication, (1977).
Fieser et al., "Organische Chemie", 2nd Ed., 1802-1807, (1982).

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