Amyloid β protein agglutination-controlling factor

Details Amyloid β protein agglutination-controlling factor Amyloid β protein agglutination-controlling factor

2005-11-01

2005-11-01

Wax, Robert A. (Department: 1653)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S069100, C435S252300, C435S252330, C435S254110, C435S254210, C435S320100, C435S325000, C435S358000, C536S023500

Reexamination Certificate

active

06960435

ABSTRACT:
The present invention provides: proteins suppressing or promoting the aggregation or deposition of amyloid-β protein; polynucleotides encoding the proteins; a method for screening a compound suppressing or promoting the aggregation or deposition of amyloid-β protein; and therapeutic agents for treating or preventing Alzheimer's diseases comprising a compound that regulates the activity of a protein suppressing or promoting the aggregation or deposition of amyloid-β protein.

REFERENCES:
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patent: 99/55865 (1999-11-01), None
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Y. Du et al.: “α2-Macroglobulin attenuates β-amyloid peptide 1-40 fibril formation and associated neurotoxicity of cultured fetal rat” Jounral of Neurochemistry, vol. 70, No. 3, pp. 1182-1188, 1998.
M.M. Pallito et al.: “Recognition sequence design for peptidyl modulators of β-amyloid aggregation and toxicity” Biochemistry, vol. 38, No. 12, pp. 3570-3578, 3/99.
H. Levine III, et al.: “Quantification of -sheet amyloid fibril structures with thioflavin T” Methods in Enzymology, vol. 309, pp. 274-284, 10/99.

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