Amyloid precursor proteins and method of using same to assess ag

Details Amyloid precursor proteins and method of using same to assess ag Amyloid precursor proteins and method of using same to assess ag

1995-06-05

1997-12-30

Jacobson, Dian C.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530539, 514 12, 435 691, 4351723, C07K 14435, C07K 1447, C12N 1512

Patent

active

057032092

ABSTRACT:
This application describes a purified and isolated fragment of a nucleic acid molecule encoding an amyloid precursor mutein, wherein the fragment comprises a nucleic acid sequence encoding at least one marker and a nucleic acid sequence of about 419, about 475 or about 494 amino acid residues in which a portion thereof encodes a .beta.-amyloid protein domain. Also described is a method for screening for a compound which reduces the formation of .beta.-amyloid protein.

REFERENCES:
Sahasrabudhe, S.R. et al; J. Biol. Chem. 267:25602-25608 (1992).
Vitek, M.P. et al., Soc. Neurosci. Abstr. 17(1-2):1443 (1991).

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