Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1994-12-22
1998-03-31
Hendricks, Keith D.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
C12N 964
Patent
active
057337683
ABSTRACT:
This invention provides an APP-cleaving protein and related nucleic acid compounds. The invention also provides methods, materials and assays. The compounds of this invention will further the characterization of neurological diseases such as Alzheimer's disease and Down's syndrome.
REFERENCES:
patent: 5292652 (1994-03-01), Dovey et al.
patent: 5424205 (1995-06-01), Dovey et al.
Abraham Carmela R. et al., 174(2) Biochemical and Biophysical Research Communications 790(91).
Ishiura S., Journal of Neurochemistry 363(91).
Kang, J. et al., Gene 110 181(92).
Nelson, Robert B. and Siman, Robert, 265(7) The Journal of Biological Chemistry 3836(90).
Selkoe, Dennis J. 32 Scientific American 66(91).
Dixon Eric P.
Johnstone Edward M.
Little Sheila P.
Norris Franklin H.
Eli Lilly and Company
Gaylo Paul J.
Hendricks Keith D.
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