Amyloid precursor-like protein and uses thereof

Details Amyloid precursor-like protein and uses thereof Amyloid precursor-like protein and uses thereof

1996-08-06

1999-04-06

Hutzell, Paula K.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

530350, 530810, 4241841, 4241851, 4241931, A61K 3800

Patent

active

058919910

ABSTRACT:
The present invention is directed to isolated amyloid precursor-like proteins (APLPs), nucleotide sequences coding for and regulating expression of these protein, antibodies directed against these proteins, and recombinant vectors and host cells containing the genetic sequences coding for and regulating the expression of these protein sequences. The invention is also directed to isolated genomic. DNA, cDNA anti-sense RNA, and RNA containing the protein sequence. Antibodies can be used to detect an APLP in biological specimens, including, for example, fluid, serum or tissue samples. APLP1 and APLP2 are candidate genes for late onset familial Alzheimer's disease.

REFERENCES:
patent: 4376110 (1983-03-01), David et al.
patent: 4579821 (1986-04-01), Palmiter et al.
patent: 4666829 (1987-05-01), Glenner et al.
patent: 4728605 (1988-03-01), Fudenberg et al.
patent: 4912206 (1990-03-01), Goldgaber et al.
patent: 5221607 (1993-06-01), Cordell et al.
patent: 5441931 (1995-08-01), Sprecher et al.
Abe, K. et al., "Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells," Neurosci. Lett. 125(2):169-171 (Apr. 1991).
Abe, K. et al., "Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia rat cerebral cortex," Neurosci. Lett. 125(2):172-174 (Apr. 1991).
Anonymous, "At last, animal models for studying Alzheimer's: A tale of four mice," Biotech. Newswatch 11(15):1,4 (Aug. 1991).
Bradley, J. E. et al., "A Simple, Rapid Method for the Purification of Poly A.sup.+ RNA," Biotechniques 6(2):114-116 (1988).
Beidler, C. B. et al., "Cloning and High Level Expression of a Chimeric Antibody with Specificity for Human Carcinoembryonic Antigen," J. Immunol. 141:4053-4060 (1988).
Beltz, G. A. et al., "Isolation of Multigene Families and Determination of Homologies by Filter Hybridization Methods," Meth. Enzymol. 100:266-285 (1983).
Benes, F. M. et al., "Structural Diversity and Infrastructure of Amyloid Deposits in Alzheimer Brain," Soc. Neurosci. 13:1153, Abstr. No. 316.15 (1987).
Benoist, C. and P. Chambon, "In vivo sequence requirements of the SV40 early promoter region," Nature 290:304-310 (1981).
Better, M. et al., "Escherichia coli Secretion of an Active Chimeric Antibody Fragment," Science 240:1041-1043 (1988).
Birghauer E. and F. Solomon, "A Marginal Band-associated Protein Has Properties of Both Microtubule-and Microfilament-associated Proteins," J. Cell. Biol. 109:1609-1620 (1989).
Blobel, G., "Intracellular protein topogenesis," Proc. Natl. Acad. Sci. USA 77(3):1496-1500 (1980).
Bollon, A. P. and M. Stauver, "DNA Transformation Efficiency of Various Bacterial and Yeast Host-Vector Systems" J. Clin. Hematol. Oncol. 10(2 & 3): 39-48 (1980).
Botstein, D. et al., "Making Mutations In vitro and Putting Them Back Into Yeast," in: From Gene to Protein: Translation Into Biotechnology, Ahmad, F. et al., eds., Academic Press, Inc.: New York pp. 265-274 (1982).
Brandis, J. et al., "Preparation of cDNA Libraries and the Detection of Specific Gene Sequences," in: Genetic Engineering, Setlow, J. K. et al., eds., Plenum Press: New York, pp. 299-316 (1986).
Broach, J. R., "The Yeast Plasmid 2.mu. Circle," Cell 28: 203-204 (1982).
Broach, J. R., "The Yeast Plasmid 2.mu. Circle," in: The Molecular Biology of the Yeast Saccharomyces: Life Cycle and Inheritance, Strathern, J. N. et al., eds., Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY, pp. 445-470 (1981).
Brook, J. D. et al., "The physical map of chromosome arm 19q: some new assignments, confirmations and re-assessments," Hum. Genet. 87(1): 65-72 (May. 1991).
Bush, A. I. et al., "Specific and Saturable Binding of the Amyloid Protein Precursor of Alzheimer's disease by Zinc(II)," Neurobiol. Aging 13 (Suppl 1):S84 Abstr. No. A. 331 (Jul. 1992).
Buxbaum, J. D. et al., "Processing of Alzheimer .beta./A4 amyloid precursor protein: Modulation by agents that regulate protein phosphorylation," Proc. Natl. Acad. Sci. USA 87:6003-6006 (1990).
Chartier-Harlin, M.-C. et al., "Early-onset Alzheimer's disease caused by mutations at condon 717 of the .beta.-amyloid precursor protein gene," Nature 353:844-846 (Oct. 1991).
Chen, W.-J et al., "NPXY, a Sequence Often Found in Cytoplasmic Tails, Is Required for Coated Pit-mediated Internalization of the Low Density Lipoprotein Receptor," J. Biol. Chem. 256(6):3116-3123 (1990).
Cheng, S. V. et al., "Comparative mapping of DNA markers from the familial Azheimer disease and Down syndrome regions of human chromosome 21 to mouse chromosmes 16 and 17," Proc. Natl. Acad. Sci. USA 85:6032-6036 (1988).
Church, G. M. and W. Gilbert, "Genomic sequencing," Proc. Natl. Acad. Sci. USA 81:1991-1995 (1984).
Church, G. M. and W. Gilbert, "The Genomic Sequencing Technique," in: Medical Genetics: Past. Present. Future , Alan R. Liss, Inc.: New York, pp. 17-21 (1985).
Cullen, B. R., "Use of Eukaryotic Technology in the Functional Analysis of Cloned Genes," Meth. Enzymol. 152:684-704 (1987).
Deen, K. C. et al., "Use of T4 DNA Polymerase Replacement Synthesis for Specific Labeling of Plasmid-Cloned Inserts,"Analytical Biochem. 135:456-465 (1983).
De Sauvage, F. and J.-N. Octave, "A Novel mRNA of the A4 Amyloid Precursor Gene Coding for a Possible Secreted Protein," Science 245 :651-653 (1989).
Donaldson, J. G. et al., "Dissociation of a 110-kD Peripheral Membrane Protein from the Golgi Apparatus Is an Early Event in Brefeldin A Action," J. Cell Biol. 111(6):2295-2306 (1990).
Esch, F. S. et al., "Cleavage of Amyloid .beta. Peptide During Constitutive Processing of Its Precursor," Science 248: 1122-1124 (1990).
Estus, S. et al., "Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor," Science 255 :726-728 (Feb. 1992).
Fabrice, D. et al., "A new TaqI polymorphism detected by the cDNA encoding amyloid beta protein of Alzheimer's disease," Chem. Abstr. 108:154, Absr. No. 17130p (1988).
Feinberg, A. P. and B. Vogelstein, "A Technique for Radiolabeling DNA Restriction Endonuclease Fragments to High Specific Activity," Analytical Biochem. 132 :6-13 (1983).
Fidani, L. et al., "Screening for mutations in the open reading frame and promotor of the .beta.-amyloid precursor protein gene in familial Alzheimer's disease: identification of a Further family with APP717 Val.fwdarw.Ile," Human Mol. Genet. 1(3):165-168 (Jun. 1992).
Frohman, M. A. et al., "Rapid production of full-length cDNAs from rare transcripts: Amplification using a single gene-specific oligonucleotide primer," Proc. Natl. Acad. Sci. USA 85:8998-9002 (1988).
Gamzu, E., "Animal Behavioral Models in the Discovery of Compounds to Treat Memory Dysfunction," Ann. New York Acad. Sci. 444:370-393 (1985).
Gandy, S. et al., "Phosphorylaton of Alzheimer disease amyloid precursor peptide by protein kinase C and Ca.sup.2+ /calmodul in-dependent protein kinase II," Proc. Natl. Acad. Sci. USA 85:6218-6221 (1988).
Geissler, E. N. et al., "Stem Cell Factor (SCF), a Novel Hematopoietic Growth Factor and Ligand for c-kit Tyrosine Kinase Receptor, Maps on Human Chromosome 12 between 12q14.3 and 12qter," Somatic Cell Mol. Genet. 17(2):207-214 (Jan. 1991).
Glenner, G. G. and C. W. Wong, "Alzheimer's Disease: Initial Report of the Purification and Characterization of a Novel Cerebrovascular Amyloid Protein," Biochem. Biophys. Res. Comm. 120(2):885-890 (1984).
Goate, A. et al., "Segregation of a Missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease," Nature 349 :704-706 (Feb. 1991).
Goedert, M., "Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer's disease," EMBO J. 6(12):3627-3632 (1987).
Golde, T. E. et al., "Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives," Science 255:728-730 (Feb. 1992).
Goldgaber, D. et al., "Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease," Science 235:877-880 (1987).
Graw, S. et al., "Irradiation-Reduced Human Chromosome 21 Hybrids," Somatic Cell Mol. Gene

Affiliated with

Also associated with

Rating

Amyloid precursor-like protein and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Amyloid precursor-like protein and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amyloid precursor-like protein and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1372282