Amylin peptides

Details Amylin peptides Amylin peptides

1989-05-01

1994-11-22

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Calcitonin; related peptides

530324, 5303879, A61K 3702, C07K 710, C07K 736

Patent

active

053670523

ABSTRACT:
A biologically active peptide associated with diabetes and designated herein "amylin" and processes for preparing it and assaying for it and for Type 2 diabetes are disclosed. The invention includes peptides having the amino acid sequence KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY, substantially homologous sequences of amino acids, proamylin, as well as biologically active subfragments and conservative mutations. The peptide may be prepared from diabetic pancreata by solubilization of amyloid and isolation of the peptide by gel filtration and reverse phase chromotography. Amylin may also be synthesized, or it may be produced by recombinant DNA techniques using the disclosed nucleic acid sequences.

REFERENCES:
patent: 5112945 (1982-05-01), Westermark et al.
Cooper et al., Proc. National Acad. Sci., Purification and Characterization of A Peptide from Amyloid-rich Pancreases of Type Z Diabetic Patients, Dec. 1987, pp. 8628-8632.
Westermark et al., Proc. Natl. Acad. Sci. USA, Amyloid Fibrils in Human Insulinoma and Islets of Langerhans of the Diabetic Cat are Derived from A Neuropeptide-like Protein Jun. 1987, pp. 3881-3885.

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