Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2011-04-19
2011-04-19
Russel, Jeffrey E (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S006700, C514S006900, C514S021300, C530S324000
Reexamination Certificate
active
07928060
ABSTRACT:
The present invention relates to Amylin Family Polypeptide-6 (AFP-6) analogs, which include derivatives and fragments, related nucleic acids, expression constructs, host cells, and processes for recombinant production of the AFP-6 analogs. The AFP-6 analogs of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent conditions such as metabolic and cardiovascular disorders, e.g., obesity, diabetes, metabolic syndrome, myocardial ischemia, and increased cardiovascular risk.
REFERENCES:
patent: 5264372 (1993-11-01), Beaumont et al.
patent: 5686511 (1997-11-01), Bobo
patent: 5849883 (1998-12-01), Boone et al.
patent: 5998367 (1999-12-01), Gaeta et al.
patent: 6630169 (2003-10-01), Bot et al.
patent: 6965013 (2005-11-01), Hsu
patent: 2004/0170568 (2004-09-01), Weers et al.
patent: 2005/0197287 (2005-09-01), Mack et al.
patent: 2006/0063716 (2006-03-01), Hsu
patent: 2006/0094652 (2006-05-01), Levy et al.
patent: 2006/0094653 (2006-05-01), Levy et al.
patent: WO8304053 (1983-11-01), None
patent: WO9907404 (1999-02-01), None
patent: WO9925727 (1999-05-01), None
patent: WO9925728 (1999-05-01), None
patent: WO03026591 (2003-04-01), None
patent: WO03057235 (2003-07-01), None
patent: WO2004048547 (2004-06-01), None
Becker, et al, “Procalcitonin and the Calcitonin Gene Family of Peptides in Inflammation, Infection and Sepsis: A Journey from Calcitonin Back to Its Precursors,” Journal of Clinical Endocrinology & Metabolism (2004) 89 (4) 1512-1525.
Beltowski, et al, Adrenomedullin—What Do We Know 10 Years Since Its Discovery? Polish Journal of Pharmacology (2004) 56:5-27.
Campfield, et al, “Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks” Science (1995) 269:546-549.
Chang, et al, “Intermedin, A Novel Calcitonin Family Peptide That Exists In Teleosts as Well as in Mammals: A Comparison With Other Calcitonin/INtermedin Family Peptides in Vertebrates,” Peptides (2004) 25(10):1633-1642.
D'Santos, et al, “Stimulation of Adenylate Cyclase by Amylin in CHO-K1 Cells,” Mol. Pharmacol. (1992) 41 (5):894-899.
Dumont, et al, “Receptor Autoradiography as Mean to Explore the Possible Functional Relevance of Neuropeptides: Focus on New Agonists and Antagonists to Study Natriuretic Peptides, Neuropeptide Y and Calcitonin Gene-Related Peptides,” (2004) 25:365-391.
Halaas, et al, “Weight-Reducing Effects of the Plasma Protein Encoded by the Obese Gene,” Science (1995) 269 (5223):543-546.
Hinson, et al, “Andrenomedullin, a Multifunctional Regulatory Peptide,” Endocrin Reviews 21(2):138-167, (2000).
Kato, et al, “Receptors for adrenomedullin in human vascular endothelial cells,” Eur J Pharmacol. (1995) 289:383-385.
Kozak M., “At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells,” J Mol Biol. Aug. 20, 1987;196(4):947-950.
Kozak M., “An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs,” Nucleic Acids Res. Oct. 26, 1987;15(20):8125-8148.
Kuestner, et al, “Cloning and characterization of an abundant subtype of the human calcitonin receptor,” Mol Pharmacol (1994) 46: 246-255.
Kurihara, et al, “Targeted Disruption of Adrenomedullin and αCGRP Genes Reveals Their Distinct Biological Roles,” Hypertens. Res. (2003) 26 Suppl:S 105-108.
Muff, et al, “Comparison of a Calcitonin Gene-Related Peptide Receptor in a Human Neuroblastoma Cell Line (SK-N-MC) and a Calcitonin Receptor in a Human Breast Carcinoma Cell Line (T47D)α,” Annals New York Academy of Science (1992) 657:106-116.
Nagaya, et al, “Repeated inhalation of adrenomedullin ameliorates pulmonary hypertension and survival in monocrotaline rats,” Am J Physiol Heart Circ Physiol (2003) 285: H2125-H2131.
Nicholls, et al, “Bioactivity of adrenomedullin and proadrenomedullin N-terminal 20 peptide in man” Peptides (2001) 22:1745-1752.
Ogoshi, M., et al, “Identification of a Novel Adrenomedullin Gene Family in Teleost Fish,” Biochemical and Biophysical Research Communications (2003) 311(4):1072-1077.
Pelleymounter, et al, “Effects of the Obese Gene Product on Body Weight Regulation in Ob/Ob Mice,” Science (1995) 269(5223):540-543.
Roh, et al, “Intermedin Is a Calcitonin/Calcitonin Gene-related Peptide Family Peptide Acting Throught the Calcitonin Receptor-like Receptor/Receptor Activity-modifying Protein Receptor Complexes,” J. Biol. Chem. (2004) 279(8):7264-7274.
Sandberg, et al, “New Chemical Descriptors Relevant for the Design of Biologically Active Peptides, A Multivariate characterization of 87 Amino Acids,” J. Med. Chem. (1998) 41:2481-2491.
Sexton, et al, “Calcitonin,” Current Medicinal Chemistry (1999) 6:1067-1093.
Takei, et al. “Identification of Novel Adrenomedullin in Mammals: A Potent Cardiovascular and Renal Regulator,” FEBS Letters (2004) 556(1):53-58.
Taylor, et al, “Adrenomedullin Inhibits Feeding in the Rat by a Mechanism Involving Calcitonin Gene-related Peptide Receptors,” Endocrinology (1996) 137: 3260-3264.
Wimalawansa, S. J., “Amylin, Calcitonin Gene-Related Peptide, Calcitonin, and Adrenomedullin: a Peptide Superfamily,” Critical Reviews in Neurobiology (1997) 11(2&3):167-239.
Erickson Mary
Ghosh Soumitra
McQuaid Sarah
Pittner Richard
Srivastava Ved
Amylin Pharmaceuticals Inc.
Russel Jeffrey E
LandOfFree
Amylin family polypeptide-6 (AFP-6) analogs and methods of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Amylin family polypeptide-6 (AFP-6) analogs and methods of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amylin family polypeptide-6 (AFP-6) analogs and methods of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2658943