Amylin antagonist peptides and uses therefor

Details Amylin antagonist peptides and uses therefor Amylin antagonist peptides and uses therefor

1991-11-19

1996-12-03

Woodward, Michael P.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Insulin; related peptides

530324, A61K 3822, C07K 14575

Patent

active

055809537

ABSTRACT:
Compounds which inhibit amylin activity are provided. These compounds may be used in the treatment of conditions where it is of benefit to reduce amylin activity, including the treatment of Type 2 diabetes mellitus, impaired glucose tolerance, obesity and insulin resistance.

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Cooper, G. J. S., et al. Proc. Natl. Acad. Sci USA, vol. 85, pp. 7763-7766 (Oct. 1988).
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Munson, P. J., et al., Analytical Biochemistry, 107, pp. 220-239 (1980).
Cooper, G. J. S., et al., Biochimica et Biophysica Acta., 1014, pp. 247-258 (1989).

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