Amylin agonist pharmaceutical compositions containing insulin

Details Amylin agonist pharmaceutical compositions containing insulin Amylin agonist pharmaceutical compositions containing insulin

1998-01-09

2000-10-24

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 3, 514 4, 514 21, 514866, A61K 3800, A61K 3828

Patent

active

061367842

ABSTRACT:
The present invention is concerned with a pharmaceutical formulation in a container, for example, a vial, prefilled cartridge, prefilled syringe or disposable pen, comprising approximately 0.01 to about 0.5% (w/v) amylin agonist, preferably pramlintide, in an aqueous system along with approximately 0.02 to about 0.5% (w/v) of an acetate, phosphate, citrate, or glutamate buffer to a pH of the final composition of approximately 3.0 to about 6.0 as well as approximately 1.0 to 10% (w/v) of a carbohydrate or polyhydric alcohol tonicifier; and, optionally, approximately 0.005 to 1.0% (w/v) of a preservative selected from the group consisting of m-cresol, benzyl alcohol, parabens and phenol. These formulations maintain stability upon storage under refrigerated or room temperature conditions. Such formulations can be further combined with insulin in the same syringe for administration to a patient.

REFERENCES:
patent: 5175145 (1992-12-01), Cooper
patent: 5686411 (1997-11-01), Gaeta et al.

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