Amylin activity assays

Details Amylin activity assays Amylin activity assays

1995-04-14

2000-04-11

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Testing efficacy or toxicity of a compound or composition

514 12, 514 21, 514866, 514884, A61K 3822, A61K 4900, G01N 3315

Patent

active

060485140

ABSTRACT:
Novel methods for use in identifying or assaying compounds which can simulate the ability of amylin to cause hyperlactemia and hyperglycemia in in vivo biological models, or for use in evaluating the potency of compounds known or suspected to simulate these actions of amylin, which involve introducing test samples into in vivo test systems and determining the presence or amount of a rise in lactate, or determining the presence or amount of a rise in lactate and a rise in glucose, following test sample administration.

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