Amylase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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426656, 530374, 530395, 530416, A23J 112, A61K 3816, C07K 118, C07K 14415

Patent

active

054440467

ABSTRACT:
An amylase inhibitor consisting essentially of a protein constructed of 248 amino acid residues having two subunits, each identified as SEQ ID NO:1, in which a single band is observed at a mobility of 0.26 by polyacrylamide gel electrophoresis. The amylase inhibitor can be extracted from wheat and purified by absorption on a cation exchange resin. It is useful for inhibiting an increase in blood glucose level, controlling insulin secretion, suppressing appetite, and as a food additive. The new amylase inhibitor can be used in combination with a protein composed of two subunits, each identified as SEQ ID NO:2, the total content of both proteins being not less than 20% by weight.

REFERENCES:
patent: 3950319 (1976-04-01), Schmidt et al.
patent: 5084275 (1992-01-01), Maeda et al.
patent: 5093315 (1992-03-01), Maeda et al.
patent: 5332803 (1994-07-01), Miyazaki et al.
Biochimica et Biophysics Acta, vol. 828, 1985, pp. 213-221, K. Maeda, et al., "Complete Amino Acid Sequence Of An Alpha-Amylase Inhibitor In Wheat Kernel (0.19-Inhibitor)".
"The Complete Amino Acid Sequence Of A Major Wheat Protein Inhibitor Of .alpha.-Amylase", Nizar Kashlan and Michael Richardson, Phytochemistry, vol. 20, No. 8, pp. 1781-1784, 1981.
"New Dimeric Inhibitor Of Heterologous a-Amylases Encoded By A Duplicated Gene In The Short Arm Of Chromosome 38 Of Wheat . . . ", Euro., J. Biochem., 183, pp. 37-40, 1989.
"Influence Of An a-Amylase Inhibitor (Bay d 7791) On Blood Glucose, Serum Insulin And NEFA in Starch Loading Tests in Rats, Dogs, and Man", Springer-Vorlag, Diabetologia, 9, pp. 99-101, 1973.
"Disc Electrophoresis-II, Method And Application To Human Serum Proteins", Baruch J. Davis, Annals New York Academy Of Sciences, 121, pp. 404-427, 1964.
"Studies Of Glutenin. II. Relation Of Variety, Location Of Growth, And Baking Quality To Molecular Weight Distribution Of Subunits", R. A. Orth et al., Cereal Chemists, vol. 50, pp. 190-197, 1973.
"Complete Amino Acid Sequence Of An .alpha.-Amylase Inhibitor In Wheat Kernel", K. Maeda, T. Hase, and H. Matsubara, Biophysica Acta, 743, pp. 52-57, 1983.

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