Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Plant proteins – e.g. – derived from legumes – algae or...
Patent
1997-01-14
1998-03-10
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Plant proteins, e.g., derived from legumes, algae or...
530374, 514 2, 514 8, 514 12, C07K 302, C07K 324, C07K 1510, A61K 3816
Patent
active
057262918
ABSTRACT:
An amylase inhibitor consisting of a protein constructed of 244 amino acid residues having two subunits each identified as SEQ ID NO:1, in which a single band is observed at a mobility of 0.26 by polyacrylamide gel electrophoresis, and having a high inhibitory activity against human pancreatic .alpha.-amylase to inhibit an increase in blood glucose level, control an insulin secretion or maintain the duration in a feeling of satiety for diet. The amylase inhibitor can be used alone or in combination with other known amylase inhibitors.
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patent: 5444046 (1995-08-01), Miyazaki et al.
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Rosa Sanchez-Monge, et al., "New Dimeric Inhibitor of Heterologous .alpha.-amylases Encoded by a Duplicated Gene in the Short Arm of Chromosome 3B of Wheat (Triticum aestivum L.)", Eur. J. Biochem, vol. 183, (1989), pp. 37-40.
Nizar Kashlan, et al., "The Complete Amino Acid Sequence of a Major Wheat Protein Inhibitor of .alpha.-Amylase", Phytochemistry, vol. 20, No. 8, (1981), pp. 1781-1784.
Baruch J. Davis, "Disc Electrophoresis--II Method and Application to Human Serum Proteins", Annals New York Academy of Sciences, vol. 121, (1964), pp. 404-427.
K. Maeda, et al., "Complete Amino Acid Sequence of an .alpha.-Amylase Inhibitor in Wheat Kernel", Biochimica et Biophysica Acta, vol. 743, (1983), pp. 52-57.
Miyazaki Toshiyuki
Morimoto Toshihisa
Murayama Ryuji
Borin Michael
Nagata Sangyo Co. Ltd.
Nisshin Flour Milling Co. Ltd.
Tsang Cecilia J.
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