Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1992-05-04
1994-01-11
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
424122, 435195, 4352532, 4352535, A61K 3500, C12R 101, C12P 104
Patent
active
052780643
ABSTRACT:
Fermentation product A87689 is produced by a strain of Amycolatopsis mediterranei selected from NRRL 18815 and NRRL 18851, or an A87689-producing mutant thereof. A87689, its C.sub.1-6 -alkyl ether and C.sub.1-6 -alkanoyl ester derivatives and pharmaceutically acceptable salts thereof are phospholipase A.sub.2 inhibitors that are useful as antiinflammatory agents. Fermentation products known as BU-3889V, its components and pharmaceutically acceptable salts thereof, are phospholipase A.sub.2 inhibitors that are also useful as antiinflammatory agents.
REFERENCES:
Kusumi, T., et al., The Structures of Quartromicins A1, A2, A3: Novel Macrocyclic Antiviral Antibiotics Possessing Four Tetronic Acid Moieties, J. Am. Chem. Soc., 113:8947-8948 (1991).
A. Fredenhagen, G. Fendrich, F. Marki, J. Gruner, F. Raschdorf, and H. Peter, "Duramycins B and C, Two New Lanthionine Containing Antibiotics as Inhibitors of Phospholipase A2," J. Antibiotics 43: 1403-1412 (1990).
K. Nakagawa and A. Torikata, "Microbial Conversion of Milbemycins: 30-Oxidation of Milbemycin A.sub.4 and related Compounds by Amycolatopsis autotrophica and Amycolatopsis mediterranei" J. Antibiotics 43: 1321-1328 (1990).
Berry Dennis R.
Dantzig Anne H.
Debono Manuel
Hamill Robert
Molloy R. Michael
Eli Lilly and Company
Fontana Steven A.
Lilling Herbert J.
Whitaker Leroy
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