Amplifier molecules for enhancement of diagnosis and therapy

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent

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424450, 530383, 528422, 548101, 548524, 548486, 560 39, 560 42, 560171, 560164, 564 27, 564165, 556 45, 556110, 556138, C12N 996, C07C 6980, C07D20948, C07D20738

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active

051357372

ABSTRACT:
Disclosed are amplifier molecules: various organic compounds having branched structures terminating with amine groups to which pharmacologically active groups can be chemically attached. A number of MRI contrast-enhancing agents were synthesized, each comprising plural active groups, such as stable nitroxides and complexes of trivalent metal cations. Such syntheses were successfully performed using a number of amplifiers having different branched structures, demonstrating the general utility of the pertinent chemistry in the synthesis of amplifiers having any of a wide variety of pharmacologically active groups. Amplifiers were also synthesized having linkers terminating with chemically reactive groups such as isothiocyanates, which render the amplifier bifunctional: attachable to polymers, biomacromolecules, or other biocompatible entity possessing multiple reactive sites such as terminal amines. Via such chemistry, the amplifiers are attachable to monoclonal antibodies for concentration of pharmacologically active groups at a desired site in the body.

REFERENCES:
patent: 4099918 (1978-07-01), Keana
patent: 4997913 (1991-03-01), Hellstrom et al.
Reddy et al Chemical Abstracts vol. 106, 1987, Abstract 33439k.
Morrison and Boyd, Organic Chemistry [Boston, Allyn and Bacon, 1979] pp. 876-880.
Borman, S., "Bioconjugate Chemistry Attracts Growing Interest," Chem. and Eng. News, May 8, 1989, p. 25.
Curtet, C. et al., "Selective Modification of NMR Relaxation Time in Human Colorectal Carcinoma by Using Gadolinium-Diethylenetriaminepentaacetic Acid Conjugated with Monoclonal Antibody 19-9," Proc. Natl. Acad. Sci. USA 83:4277 (1986).
Ehman, R. L. et al., "Enhanced MRI of Tumors Utilizing a New Nitroxyl Spin Label Contrast Agent," Mag. Res. Imaging 3:89 (1985).
Keana, J. F. W. and Prabhu, V. S., "trans-2,5-Dimethyl-2,5-bis(3-aminopropyl)-pyrrolidinyl-1-oxy: A trans-Diamino Azethoxyl Nitroxide," J. Org. Chem. 51:4300 (1986).
Keana, J. F. W. and Ogan, M. D., "Functionalized Keggin-and Dawson-Type Cyclopentadienyltitanium Heteropolytungstate Anions: Small, Individually Distinguishable Labels for Conventional Transmission Electron Microscopy. 1. Synthesis," J. Am. Chem. Soc. 108:7951 (1986).
Keana, J. F. W. et al., "Functionalized Keggin-and Dawson-Type Cyclopentadienyltitanium Heteropolytungstate Anions: Small, Individually Distinguishable Labels for Conventional Transmission Electron Microscopy. 2. Reactions," J. Am. Chem. Soc. 108:7957 (1986).
Keana, J. F. W. et al., "Synthesis of Spiro Heterocyclic Nitroxides Derived From 4-Piperidone," J. Org. Chem. 53:2365 (1988a).
Keana, J. F. W. et al., "Synthesis and Chemistry of N-Oxygenated Pyrroles: Crystal and Molecular Structure of a Highly Stable N-Hydroxypyrrole 18-Crown Ether Hydrate," J. Org. Chem. 53:2268 (1988b).
Keana J. F. W. and Pou, S., "Synthesis and Properties of Some Nitroxide .alpha.-Carboxylate Salts," J. Org. Chem. 54:2417 (1989).
Newkome, G. R. et al., "Cascade Molecules: Synthesis and Characterization of a Benzene[9].sup.3 -Arborol," J. Am. Chem. Soc. 108:849 (1986).
Swyers, J., "Monoclonal Antibodies Have Diagnostic, Therapeutic Potential," Res. Resources Reporter, U.S. Dept. of Health & Human Services, vol. XIII, No. 4, pp. 7-9 (Apr. 1989).
Unger, E. C. et al., "Magnetic Resonance Imaging Using Gadolinium labeled Monoclonal Antibody," Investig. Radiol. 20:693 (1985).
Wesbey, G. E. et al., "Paramagnetic Pharmaceuticals for Magnetic Resonance Imaging," Physiol. Chem. & Phys. & Med. NMR 16:145 (1984).
Westerberg, D. A. et al., "Synthesis of Novel Bifunctional Chelators and Their Use in Preparing Monoclonal Antibody Conjugates for Tumor Targeting," J. Med. Chem. 32:236 (1989).
Koppel, Gary A., "Recent Advances with Monoclonal Antibody Drug Targeting for the Treatment of Human Cancer", Biconjugate Chem., 1:13-23 (1990).
Lauffer, Randall B., "Paramagnetic Metal Complexes as Water Proton Relaxation Agents for NMR Imaging: Theory and Design", Chem. Rev., 87:901-927 (1987).
Solomons, T. W., "Conjugated Unsaturated Systems", Organic Chemistry, pp. 470-474 (1988).
Kozak, Robert W. et al., "Radionuclide-conjugated monoclonal antibodies: a synmthesis of immunology, inorganic chemistry and nuclear science", Tibtech, pp. 259-264 (Oct. 1986).
Keana, John F. W. et al., "Nitroxides as Potential Contrast Enhancing Agents for MRI Application: Influence of Structure on the Rate of Reduction by Rat Hepatocytes, Whole Liver Homogenate, Subcellular Fractions, and Ascorbate", Magnetic Resonance in Medicine, 5:525-536 (1987).
Keana, J. F. W., "Synthesis and Chemistry of Nitroxide Spin Labels," Spin Labeling in Pharmacology, Chapter 1 (1984).

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