Amplification of the VB.sub.12 uptake system using polymers

Details Amplification of the VB.sub.12 uptake system using polymers Amplification of the VB.sub.12 uptake system using polymers

1993-05-24

1995-09-12

Nutter, Nathan M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

530812, 530815, 530816, 424484, 424485, 424486, 424487, 424488, 514656, C08F28300, C08G 6391, A01N 3302

Patent

active

054497205

ABSTRACT:
The invention relates to the oral delivery of peptide and protein pharmaceuticals using the vitamin B.sub.12 (VB.sub.12) uptake system, with the delivery being amplified using polymers. More particularly, the invention concerns a complex having the general formula:

REFERENCES:
patent: 4968742 (1990-11-01), Lewis et al.
patent: 5206219 (1993-04-01), Desai
patent: 5225182 (1993-07-01), Sharma
patent: 5258453 (1993-11-01), Kopecek et al.
patent: 5308889 (1994-05-01), Rhee et al.
Rihova et al., "Biological Properties of Targetable Poly[N-(2-Hydroxypropyl)Methyacrylamide]-Antibody Conjugates," J. Control Rel. 2:289-310 (1985).
Rejmanova et al., "Polymers Containing Enzymatically Degradable Bonds, 2 Poly[N-(2-hydroxypropyl)methacrylamide] Chains Connected by Oligopeptide Sequences Cleavable by Chymotrypsin," Makoromol. Chem. 182: 1899-1915 (1981).
Schneider et al., Comprehensive B.sub.12, Verlag Walter de Gruyter & Co., New York, 1987. (Index only).

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