Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-04-07
1995-05-30
Parr, Margaret
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 232, 536 243, 435 6, C07H 2102, C07H 2104, C12Q 168
Patent
active
054202639
ABSTRACT:
A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or detecting increased expression of gene products is diagnostic of tumorigenesis. Human MDM2 protein binds to human p53 and allows the cell to escape from p53-regulated growth.
REFERENCES:
Cahilly-Snyder et al., Somat, Cell. Mol. Genet. 13:235-244 (1987) "Molecular Analysis and Chromosomal Mapping . . . "
Fakharzadeh, et al., "Tumorigenic Potential Associated with Enhanced Expression of a GEne That is Amplified in a Mouse Tumor Cell Line", The EMBO Journal, 10(6):1565-1569 (1991).
Hinds, et al., "Mutant p53 DNA Clones From Human Colon Carcinomas Cooperate With Ras in Transforming Primary Rat Dells: A Comparison of the Hot Spot Mutant Phenotypes", Cell Growth & Differentiation, 1:561-580 (1990).
Romkes, et al., "Cloning and Expression of cDNA for Multiple Members of the Human Cytochrome P450IIC Subfamily", Biochemistry, 30(13):3247-3255 (1991).
Momand, et al., "The MDM2 Oncogene Product Forms a Complex with the p53 Protein and Inhibits p53-Mediated Transactivation," Cell:69:1237-1245 (1992).
Oliner, et al., "Amplification of a Gene Encoding a p53-Associated Protein in Human Sarcomas", Nature, 358:80-83 (1992).
Ladanyi, et al., "MDM2 Gene Amplificatin in Metastatic Osteosarcoma", Cancer Research, 53:16-18 (1993).
Leach, et al., "p53 Mutation and MDMS Amplification in Human Soft Tissue Sarcomas", Cancer Research 53:2231-2234 (1993).
Oliner, et al., "Oncoprotein MDM2 Conceals the Activation Domain of Tumour Suppressor p53", Nature, 362(6423):857-860 (1993).
Burrell Marilee
Hill David E.
Kinzler Kenneth W.
Vogelstein Bert
Campbell Eggerton
Parr Margaret
The Johns Hopkins University
LandOfFree
Amplification of human MDM2 gene in human tumors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Amplification of human MDM2 gene in human tumors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amplification of human MDM2 gene in human tumors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-363008