Amplification method for detection of human PF4A receptors

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

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435 6, 536 243, 536 2431, 536 2433, C12P 1934, C12Q 168, C07H 2104

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055717020

ABSTRACT:
The cDNA encoding a member of or a class of novel PF4A receptors has been identified in human tissue. Provided herein is nucleic acid sequence of a PF4A receptor (the IL-8 receptor) useful as a diagnostic and in the recombinant preparation of PF4A receptors. The PF4A receptor is used in the preparation and purification of antibodies capable of binding to the receptor, and in diagnostic assays.

REFERENCES:
patent: 4683202 (1987-07-01), Mullis
patent: 5374506 (1994-12-01), Murphy
Thomas et al, (Nov. 1990), "Molecular cloning of the fMet-Leu-Phe receptor from neutrophils", J. Biol. Chem. 265(33):20061-20064.
Davis et al, (1986), "Basic Methods in Molecular Biology", Elsevier, New York, NY, pp. 68-87.
Holmes et al, (Sep. 1991), "Structure and functional expression of a human interleukin-8 receptor", Science 253:1278-1280.
Murphy et al, (Sep. 1991), "Cloning of complementary DNA encoding a functional human interleukin-8 receptor", Science 253:1280-1283.
Poncz et al, (1988), "Analysis of the human platelet factor 4 (PF4) gene reveals gene duplication and a possible alternative PF4 (PF4alt) protein", Clin. Res. 36(3):568A.
Thomas et al, (Aug. 1991), "The interleukin-8 receptor is encoded by a neutrophil-specific cDNA clone, F3R", J. Biol. Chem. 266(23):14839-14841.
Beckman et al, (Sep. 1991), "Molecular characterization of the interleukin-8 receptor", Biochem. Biophys. Res. Comm. 179(2):784-789.
Libert et al, (1989), "Selective amplification and cloning of four new members of the G protein coupled receptor family", Science 244:569-572.
Sommer et al, (1989), "Minimal homology requirements for PCR primers", Nucleic Acids Res. 17(16):6749.
Besemer et al., "Specific Binding, Internalization, and Degradation of Human Neutrophil Activating Factor by Human Neutrophil Activating Factor by Human Polymorphonuclear Leukocytes" Journal of Biological Chemistry 264:17409-17415 (1989).
Boulay et al., "Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA" Biochem. Biophys. Res. Comm. 168(3):1103-1109 (1990).
Chuntharapai et al., "Generation and characterization of monoclonal antibodies (mAbs) to human IL 8 receptor A" J. Immunol. (abstract #708) 150(8(2)):126A (Apr. 1993).
Chuntharapai et al., "Neutralizing monoclonal antibodies to human IL-8 receptor A map to the NH.sub.2 -terminal region of the receptor" J. Immunol. 152(4):1783-1789.
D'Andrea et al., "Expression Cloning of the Murine Erythropoietin Receptor" Cell 57:277-285 (1989).
Gayle III et al., "Importance of the Amino Terminus of the Interleukin-8 Receptor in Ligand Interactions" Journal of Biological Chemistry 268(10):7283-7289 (1993).
Gerard & Gerard, "The chemotactic receptor for human c5a anaphylatoxin" Nature 349:614-617 (1991).
Grob et al., "Characterization of a Receptor for Human Monocyte-derived Neutrophil Chemotacic Factor/Interleukin-8" Journal of Biological Chemistry 265(14):8311-8316 (1990).
Hammond et al., "Generation of neutralizing antibodies to human interleukin-8 (IL8) receptors" J. Cell Biochem. (Suppl. 18B) 318:Abstract #0108 (1994).
Hebert et al., "Partial functional mapping of the human interleukin-8 type A receptor" Journal of Biological Chemistry 268(25):18549-18553 (1993).
Holmes et al., "Structure and functional expression of a human interleukin-8 receptor" Science 253(5025):1278-1280 (Sep. 13, 1991).
LaRosa et al., "Amino terminus of the interleukin-8 receptor is a major determinant of receptor subtype specificity" Journal of Biological Chemistry 267(35):25402-25406 (1992).
Lee et al., "Characterization of Two High Affinity Human Interleukin-8 Receptors" Journal of Biological Chemistry 267(23):16283-16287 (1992).
Murphy and Tiffany, "Cloning of complementary DNA encoding a functional human interleukin-8 receptor" Science 253(5025):1280-1283 (Sep. 13, 1991).
Ramachandran et al., "The Structural and Functional Interrelationships of Muscarinic Acetylcholine Receptor Subtypes" Bioessays 10:54-57 (1989).
Samanta et al., "Identification and characterization of specific receptors for monocyte-derived neutrophil chemotactic factor (MDNCF) on human neutrophils" Journal of Experimental Medicine 169:1185-1189 (1989).
Saragovi et al., "The Murine Interleukin 2 Receptor: Irreversible Cross-Linking of Radiolabeled Interleukin 2 to High Affinity Interleukin 2 Receptors Reveals a Noncovalently Associated Subunit" J. Immunol. 139(6):1918-1926 (Sep. 15, 1987).
Sims et al., "cDNA Expression Cloning of the Il-1 Receptor, a Member of the Immunoglobulin Superfamily" Science 241:585-589 (1988).
Thomas et al., "Molecular cloning of the fMet-Leu-Phe receptor from neutrophils" Journal of Biological Chemistry (published erratum appears in J Biol Chem 1992 Jul 5; 267(19):13780) 265(33):20061-20064 (Nov. 25, 1990).
Ye et al., "Inhibition of IL-8 binding to the type B IL-8 receptor by an anti-IL-8 receptor antibody" Faseb J. (Abstract #786) 8(4-5):A136 (1994).

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