Amplification based polymorphism detection

Details Amplification based polymorphism detection Amplification based polymorphism detection

2007-07-31

2007-07-31

Chunduru, Suryaprabha (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091200, C536S024310, C536S024320, C536S024330

Reexamination Certificate

active

09747538

ABSTRACT:
An improved method of amplifying nucleic acids comprising the use of four discrete temperature steps in a thermocyclic amplification reaction, as well as, a method of detecting large nucleic acid insertions or deletions such as those that occur from gene duplication or deletion.

REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 5210015 (1993-05-01), Gelfand et al.
patent: 5399491 (1995-03-01), Kacian et al.
patent: 5424414 (1995-06-01), Mattingly
patent: 5464764 (1995-11-01), Capecchi et al.
patent: 5582989 (1996-12-01), Caskey et al.
patent: 5648482 (1997-07-01), Meyer
patent: 5792607 (1998-08-01), Backman et al.
patent: 5925517 (1999-07-01), Tyagi et al.
patent: 6143529 (2000-11-01), Lapidus et al.
patent: 6232079 (2001-05-01), Wittwer et al.
patent: 6361940 (2002-03-01), Van Ness et al.
patent: 320308 (1989-06-01), None
patent: 463395 (1992-01-01), None
patent: 9732040 (1997-09-01), None
patent: 9848052 (1998-10-01), None
patent: WO 98/48052 (1998-10-01), None
Johansson I et al. PCR-based genotyping for duplicated and deleted CYP2D6 genes. Pharmacogenetics, vol. 6, pp. 351-355, 1996.
Labuda D et al. Rapid detection of CYP1A1, CYP2D6, and NAT variants by multiplex polymerase chain reaction and allel-specific oligonucleotide assay. Anal Biochem., vol. 275, pp. 84-92, 1999.
Johansson et al. PCR-based genotyping for duplicated and deleted CYP2D6 genes. Pharmacogenetics, vol. 6, pp. 351-355, 1996.
Evans et al. Genetic basis for a lower prevalence of deficient CYP2D6 oxidtive drug metabolism phenotypes in Black Americans. J. Clin. Invest., vol. 91, pp. 2150-2154, 1993.
Steen et al. Detection of the poor metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology. Pharmacogenetics, vol. 5, pp. 215-223, 1995.
Daly, AK, Steen, VM, Fairborther, KS, and Idle, JR; Methods in Enzymology, vol. 22, Chapter 22 (1996).
Wang, S-L, Huang, J-D, Lai, M- D, Lui, B-H, and Lai, M -L; Clinical Pharmacology and Therapeutics, vol. 53, pp. 410-418 (1993).
Wetmur, J. G.; Critical Reviews in Biochemistry and Molecular Biology; vol. 26, pp. 227-259 (1991).
Jou, Cynthia, et al., Amplification Based Mutation Detection; 08/844,275—PCT/US98/07909.
Johansson, I., et al., “PCR-based genotyping for duplicated and deletedCYP2D6genes”,Pharmacogenetics, 6:351-355 (1996).
Roberts, R., et al., “Rapid and Comprehensive Determination of Cytochrome P450CYP2D6Poor Metabolizer Genotypes by Multiplex Polymerase Chain Reaction”,Human Mutation, 16:77-85 (2000).
Stüven, T., et al., “Rapid detection ofCYP2D6null alleles by long distance- and multiplex-polymerase chain reaction”,Pharmacogenetics, 6:417-421 (1996).

Affiliated with

Also associated with

Rating

Amplification based polymorphism detection does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Amplification based polymorphism detection, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amplification based polymorphism detection will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3815659