Amphotericin B derivatives

Details Amphotericin B derivatives Amphotericin B derivatives

1989-06-09

1992-05-26

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

549269, 549270, C07H 1708, C07D31306

Patent

active

051169606

ABSTRACT:
Compounds of formula (I) or salts thereof: ##STR1## wherein: each R.sub.1 is independently hydrogen or a silyl protecting group; R.sub.2 is a carboxylic acid or derivative thereof; a ketone or aldehyde function; hydroxymethyl in which the hydroxyl function is optionally silylated, or substituted by hydroxy C.sub.1-4 alkyl, alkoxy C.sub.1-4 alkyl, alkoxycarbonyl C.sub.1-4 alkyl, hydroxycarbonyl C.sub.1-4 alkyl, alkyl, alkanoyl, or optionally substituted aryl or aroyl; one of X and Y is hydrogen, and the other is a sugar residue; hydroxy; optionally substituted C.sub.1-6 alkoxy or C.sub.3-8 cycloalkoxy; alkanoyloxy; thioalkanoyloxy; sulphonyloxy; halogen; or optionally substituted aryloxy, aralkyloxy or aroyloxy; or X and Y together with the carbon atom to which they are bonded are a carbonyl group or derivative thereof, are provided; their use as chemical intermediates and in the treatment of fungal infections is described.

REFERENCES:
patent: 3945993 (1976-03-01), Schaffner et al.
K. C. Nicolaou et al., "Retrosynthetic and Synthetic Chemistry on Amphotericin B . . . ", J. Chem. Soc., Chem. Commun., 1986.
Morrison et al, Organic Chemistry 3rd ed. (1979) p. 155.

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