Amphotericin B/cholesterol sulfate composition and method

Details Amphotericin B/cholesterol sulfate composition and method Amphotericin B/cholesterol sulfate composition and method

1991-12-19

1993-03-16

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

514 31, 536 65, A61K 9127, A61K 3170

Patent

active

051942666

ABSTRACT:
An amphotericin B composition containing particles of amphotericin B and cholesterol sulfate, in a molar ratio of between about 1:1 to 2:1. The particles, when stored in lyophilized form and reconstituted in an aqueous suspension, have particle sizes predominantly between about 50-250 nm. The composition has stable particle sizes in an aqueous suspension over a several-day storage period. The composition is significantly less toxic and more effective in treating fungal infection than prior amphotericin B formulations.

REFERENCES:
patent: 4822777 (1989-04-01), Abra

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