Amphiphilic polyene macrolide antibiotic compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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A61K 3170, C07H 1708

Patent

active

056060386

ABSTRACT:
Described herein is a method, and the resulting compound, for the synthesis of improved amphiphilic antibiotic agents achieved by altering the chemical structure of amphiphilic polyene macrolide compounds with an oligo(ethylene glycol) conjugate in order to raise the critical micelle concentration of the compound.

REFERENCES:
patent: 5204330 (1993-04-01), Driver et al.
Chemical Abstracts, vol. 123 (1995) No. 25196q. Yamashita et al "Micell/Monomer Control over . . . ".

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