Amphiphilic peptides and use thereof

Details Amphiphilic peptides and use thereof Amphiphilic peptides and use thereof

1990-11-06

1992-05-19

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 514 15, 514 16, 530324, 530325, 530326, 530327, 530328, A61K 3702, C07K 706, C07K 708

Patent

active

051149214

ABSTRACT:
Amphiphilic biologically active peptides and intermediates. For example, the polypeptide comprises a chain of at least four groups of four amino acids. In each group of four amino acids, two amino acids are hydrophobic, one amino acid is basic hydrophilic, and the remaining amino acid is basic or neutral hydrophilic. A preferred amino acid sequence is Ala-Phe-Ser-Lys.

REFERENCES:
patent: 4107298 (1978-08-01), Luning
patent: 4617149 (1986-10-01), DiMarchi et al.
patent: 4636489 (1987-01-01), Seemuller et al.
patent: 4659692 (1987-04-01), Lehrer et al.
patent: 4668662 (1987-05-01), Tripier
patent: 4791100 (1988-12-01), Kramer et al.
Mihara, et al, "Design and Synthesis of Basic Amphiphilic Peptides Processing Antimicrobial Activity and Their Interaction with Lipids", Peptide Chemistry (1985), pp. 223-228.
Lee, et al, "Effect of Amphiphilic Model Peptides on Biomembranes and Mast Cells", Peptide Chemistry (1985) pp. 317-320.

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