Amphiphilic diblock, triblock and star-block copolymers and...

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices

Reexamination Certificate

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C424S450000, C514S772300

Reexamination Certificate

active

07018655

ABSTRACT:
This invention relates to novel amphiphilic diblock, triblock copolymers and star-shaped block copolymers comprising a biodegradable polymer covalently attached at the polymer ends, to a hydrophilic vinyl polymer, via divalent sulfur atom; to a process for producing the block polymers; to a polymerization process which comprises subjecting the monomers capable of radical polymerization to radical polymerization in the presence of a macromolecular biodegradable chain-transfer agent; and to pharmaceutical compositions comprising the block copolymers loaded with therapeutic agents.

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Kataoka et al., “Block copolymer micelles for drug delivery: design, characterization and biological significance”, Advanced Drug Delivery Reviews 47 (2001) pp. 113-131.

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