Amphiphilic derivatives of α-C-phenyl- N-tert...

Details Amphiphilic derivatives of α-C-phenyl- N-tert... Amphiphilic derivatives of α-C-phenyl- N-tert...

2003-11-07

2010-02-02

Peselev, Elli (Department: 1623)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

C424S078310, C536S017900

Reexamination Certificate

active

07655251

ABSTRACT:
Novel compounds, derivatives of α-C-phenyl N-tert-butyl nitrone, a method for production and use thereof for the preparation of medicaments for the prevention of treatment of diseases related to oxidative stress.

REFERENCES:
patent: 5455272 (1995-10-01), Janzen et al.
patent: WO 91/05552 (1991-05-01), None
O. Ouari et al., “Synthesis of a glycolipidic amphilic nitrone as a new spin trap”,J. Org. Chem., vol. 64, 1999, pp. 3554-3556.
Floyd R.A. et al., “Protection against oxidative damage to CNS by alpha-phenyl-tert-butyl nitrone and other spin-trapping agents: a novel series of nonlipid free radical scavengers”, Emerging Strategies in Neuroprotection, 1992, pp. 252-272.
S. Tanguy, et al.; “Protection Against Reactive Oxygen Species Injuries in Rat Isolated Perfused Hearts: Effects of LPBNAH, a New Amphiphilic Spin-Trap Derived from PBN”; Cardiovascular Drugs and Therapy, vol. 20; pp. 147-149; Published Online Mar. 9, 2006.
B. Poeggeler, et al.; “Mitochondrial Medicine: Neuroprotection and Life Extension by the New Amphiphilic Nitrone LPBNAH1Acting as a Highly Potent Antioxidant Agent”; Journal of Neurochemistry, 2005, 95; pp. 962-973.
T. Asanuma, et al.; “A New Amphiphilic Derivative, N-{[4-(Lactobionamido)methyl]benzylidene}-1,1-dimethyl-2-(octylsulfanyl)ethylamine N-Oxide, Has a Protective Effect Against Copper-Induced Fulminant Hepatitis in Long-Evans Cinnamon Rats at an Extremely Low Concentration Compared with its Original Form α-Phenyl-N-(tert-butyl) Nitrone”; Chemistry & Biodiversity; vol. 4, 2007; pp. 2253-2267.

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