Amphiphilic derivatives of piperazine

Details Amphiphilic derivatives of piperazine Amphiphilic derivatives of piperazine

1994-06-07

1997-09-09

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544 1, C07D24104, C07D29500, A01N 4304, A61K 3170

Patent

active

056658796

ABSTRACT:
Novel, heterocyclic cationic amphiphile and compounds thereof are prepared that are degraded in vivo. Liposomes are produced from the cations that are used as carriers for delivering macromolecules intracellularly and may be targeted to a specific cell type.

REFERENCES:
patent: 5264618 (1993-11-01), Felgner et al.
Wang and Huang (1987) "pH-Sensitive Immunoliposomes Mediate Target-Cell-Specific Delivery and Controlled Expression of a Foreign Gene in Mouse" Proc. Natl. Acad. Sci. (USA), 84:7851-7855.
Felgner et al. (1987) "Lipofection: A Highly Efficient, Lipid-mediated DNA-transfection Procedure" Proc. Natl. Acad. Sci. (USA), 84:7413-7416.
Malone et al. "Cationic liposome-mediated RNA transfection" Proc. Natl. Acad. Sci. USA vol. 86, pp. 6077-6081, 1989.
Canonico et al. "Expression of CMV promoter driven human -1 antitrypsin gene in cultured lung endothetial cells and in the lungs of rabbits" Clinical research, vol. 39, 2, pp.219A, 1991.
Rosenfeld et al. "Adenovirus-mediated transfer of a recombinant -1-antitrypsin gene to the lung epithelium in vivo" Science, vol. 252, pp. 431. 1991.
Rosenfeld et al. "In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epthelium" Cell. vol. 58, pp. 143-155, 1992.
Friedmann "Progress toward human gene therapy" Science, vol. 244, p. 1275, 1989.
Wolff et al. "Direct gene transfer into mouse muscle in vivo" Science, vol. 247, p. 1465, 1990.
Debs et al. "Regulation of gene expression in vivo by liposome-mediated delivery of a purified transcription factor" The Journal of biological chemistry, vol. 265, 18, pp. 10189-10192, 1990.
Yoshimura et al. "Expression of the human cystic fibrosis transmembrane conductance regulator gene in the mouse lung after in vivo intratracheal plasmid-mediated gene transfer" Nucleic acids research, vol. 20, 12, pp.3233-3240, 1992.
Stribling et al. "aerosol gene delivery in vivo" Proc. Natl. Acad. Sci. USA, vol. 89, pp. 11277-11281, 1992.
Wu et al. "Receptor-mediated gene delivery and expression in vivo" The journal of biological chemistry, vol. 263, 29, pp. 14621-14624, 1988.
Nabel et al. "Site-specific gene expression in vivo by direct gene transfer into the arterial wall" Science, vol. 249, p.1285, 1990.
Hazinski et al. "Localization and induced expression of fusion genes in the rat lung", Am. J. Respir. Cell Mol. Biol., vol. 4, pp.206-209, 1991.
Brigham et al. "Rapid communicatiom: In vivo transfection of murine lungs with a functioning prokaryotic gene using a liposome vehicle", The american journal of the medical sciences, vol. 298, 4, p278, 1989.

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