Amphiphilic compounds derived from amino acids or peptides, thei

Details Amphiphilic compounds derived from amino acids or peptides, thei Amphiphilic compounds derived from amino acids or peptides, thei

1993-08-02

1995-08-29

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 514 15, 514 16, 514 17, 514 18, 514 19, 530322, 530331, 530330, 530329, 530328, 530327, 530326, 530324, A61K 3700, C07K 900

Patent

active

054460239

ABSTRACT:
Amphiphilic derivatives of amino acids or peptides are provided, comprising a polyhydroxylated hydrophilic part derived from a sugar, from a polyol, from an aminopolyol or from an oligosaccharide, and at least one hydrophobic part derived from a hydrocarbon, fluorocarbon, or a mixed fluorocarbon/hydrocarbon, saturated or unsaturated, having from 5 to 20 carbon atoms, the hydrophobic part(s) being linked to the hydrophilic part by a junction bearing an amino acid or a peptide.

REFERENCES:
patent: 2785152 (1957-03-01), Jonas
patent: 2830983 (1958-04-01), Lemieux
Liposome Technology, Targeted Drug Delivery and Biological Interaction, vol. III, (G. Gregoriadis ed., CRC Press, Inc., 1984).
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Larrabee, C. E., et al. (1979) Radiation-induced polymerization of sodium 10-undecenoate in aqueous micelle solutions. J. Polymer Sci. Polyn. Lett. Ed. 17:749-751.
LeBlanc, M. et al. (1985) Use of lymphoblastoid Namalva cell cultures in a toxicity test. Application to the monitoring of detoxification procedrues for fluorocarbons to be used as intravascular oxygen-carriers. Pharm. Res. 246.
Ogawa, T., et al. (1986) Enhancement of serum antibody production in mice by oral administration of lipophilic derivatives of muramylpeptides and bacterial lipopolysaccharides with bovine serum albumin. Chem. Abstracts 105:305q.
Okahata, Y. et al. (1987) Functional capsule membranes. Part 29. Concanavalin A-induced permeability control of capsule membranes corked with synthetic glycolipid bilayers or grafted with synthetic glycopolymers. J. Chem. Soc. Perkin Trans. II p. 1317.
Kiwada, et al., "Application of Synthetic Liposomes Based on Acyl Amino Acids or Acyl Peptides as Drug Carriers. I." Chem. Pharm. Bull., vol. 35, 1987, pp. 2935-1942.
Ozer, et al., "A Novel Drug Delivery System: Non-Ionic Surfactant Vesicles," European Journal of Pharmaceutics and Biopharmaceutics, vol 37, 1991, pp. 75-79.

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