Amphipathic PH sensitive compounds and delivery systems for deli

Details Amphipathic PH sensitive compounds and delivery systems for deli Amphipathic PH sensitive compounds and delivery systems for deli

1994-12-29

1999-10-12

Campell, Bruce R.

Chemistry: molecular biology and microbiology

Vector, per se

264 41, 264 43, 264 46, 424490, 424450, 4284022, 435455, 435458, 536 231, 514 44, C12N 1563

Patent

active

059654341

ABSTRACT:
The present invention provides amphipathic lipid compounds comprising a hydrophilic, catonic, pH-sensitive moiety, the positive charge of which moiety increases as pH decreases over the pH range of 8.0 to 4.5. Vesicular delivery systems comprising such amphipathic compounds and the use of those systems for delivering biologically active substances to cells are also provided.

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Ledley, Ham. Gene. Ther., 6:1129-1144 (1995).
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