Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-06-06
1997-03-25
Campell, Bruce R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
424450, 536 231, 552544, 562555, 935 52, 935 54, A61K 9127, A61K 4800, C07J 900, C07C26100
Patent
active
056145039
ABSTRACT:
A nucleic acid transporter to deliver a nucleic acids into cells, comprising a cationic compound having a cationic head group for binding the nucleic acid and a lipid tail for association with the membrane. A cationic compound usually is a polyamine or a short basic peptide. The lipid tail is usually selected from the group consisting of plant steroid, animal steroid, isoprenoid compound, aliphatic lipid, pore forming protein, pore forming peptides and fusogenic peptides. The cationic head and the lipid tail are linked through a carbamate linkage. When polyamine is used, it is preferably either spermidine or spermine and the nucleic acid can be any of a variety, including triplex forming oligonucleotides, antisense oligonucleotide, aptamers, ribozymes, plasmids and DNA for gene therapy. Also described is a method for treating individuals using the transporter linked to a therapeutic nucleic acid.
REFERENCES:
N Miller et al (1994) Parasitology Today 10: 92-97.
RA Stull et al (1995) Pharmaceutical Research 12: 465-483.
S Wu-Pong (1994) Pharmaceutical Technology 118: 102-114.
RW Wagner (1994) Nature 372: 333-335.
JP Behr et al (1989) Proc Natl Acad Sci USA 86:6982-6986.
Bodepudi Veeraiah
Chaudhary Nilabh
Hogan Michael E.
Jayaraman Krishna
Aronex Pharmaceuticals, Inc.
Campell Bruce R.
McDaniel C. Steven
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