Amphetamine-protein complex as immunogen for obtaining antibodie

Details Amphetamine-protein complex as immunogen for obtaining antibodie Amphetamine-protein complex as immunogen for obtaining antibodie

1989-08-31

1991-06-25

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Chemical modification or the reaction product thereof, e.g.,...

530380, 530391, 530363, 530409, 424 88, 43524027, C07K 1702, A61K 39385

Patent

active

050268279

ABSTRACT:
A N-(4-aminobutyl)amphetamine-protein complex has been synthesized to be used as an immunogen to prepare an antibody having a high affinity to methamphetamine. The antibody prepared by the use of the complex has 1,000 times the affinity to methamphetamine as that of an antibody prepared by the use of N-(4-aminobutyl)methamphetamine-protein complex as an immunogen.

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Chem. Abstract 108(15): 126018d, Yoshii et al. (1987) Nippon Hoigaku Zasshi 41(4):342-346.
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English translation copy of Yoshii et al. (1987) Nippon Hoigaku Zasshi 41(4):342-346.
Biological Abstracts, vol. 71, No. 7, 1981, Abstract No. 48539, Biological Abstracts, Inc., Philadelphia, PA, U.S.A; S. Inayama, et al.: "A Rapid and Simple Screening Method for Methamphetamine in Urine by Radioimmunoassay Using a Iodine-152-Labeled Methamphetamine Derivative".
Clinical Chemistry, vol. 35, No. 9, Sept. 1989, pp. 1998-1999; G. F. Grinstead: "Ranitidine and High Concentrations of Phenylpropanolamine Cross React in the EMIT Monoclonal Amphetamine/Methamphetamine Assay".
Clinical Chemistry, vol. 33, No. 6, 1987, p. 1080; N. R. Badcock, et al.: "Benzathine Interference in the EMIT(R)stTM Urine Amphetamine Assay".

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