Amphetamine derivatives

Details Amphetamine derivatives Amphetamine derivatives

1974-08-14

1976-12-07

Rosen, Sam

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

A61K 31135

Patent

active

039963810

ABSTRACT:
Compounds having the general formula ##STR1## or pharmaceutically acceptable salts thereof, in which formula R.sup.1 and R.sup.2 are the same or different and each represents a hydrogen atom, a lower alkyl group or a halogen atom, R.sup.3 represents a lower alkyl group or a benzyl group, R.sup.4 represents a hydrogen atom, a lower alkyl group, a benzyl group or a CH.sub.2 CH.sub.2 CH.sub.2 --bridge connected to the phenyl ring in ortho-position relative to the N-substituent, R.sup.5 represents a hydrogen atom or a methyl group and R.sup.6 represents a lower alkyl group, provided that R.sup.1 and/or R.sup.2 represents a lower alkyl group or a halogen atom when R.sup.3 represents a methyl group, R.sup.4 represents a methyl group and R.sup.5 represents a hydrogen atom; methods for the preparation thereof; intermediates useful for their preparation; pharmaceutical preparations containing at least one of these compounds; and the use thereof in the treatment of depressive states and alleviating anxiety.

REFERENCES:
patent: 3117160 (1964-01-01), Holland
patent: 3496195 (1970-02-01), Ecsery et al.
Chem. Abst., vol. 59 Subj. Index J-Z p. 1742s (1963).
Holland et al.-J. Med. Chem. vol. 6, No. 5 (1963) pp. 519-524.

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