Chemistry: electrical and wave energy – Processes and products – Processes of treating materials by wave energy
Patent
1993-04-14
1995-01-03
Gorgos, Kathryn
Chemistry: electrical and wave energy
Processes and products
Processes of treating materials by wave energy
204403, 204409, 204291, 435817, G01N 2726
Patent
active
053783328
ABSTRACT:
A biosensor system using flow injection analysis (FIA) for the analysis of glucose in human serum. The system utilizes a sensor in which the enzyme glucose oxidase (GOD) is incorporated into graphite paste modified with tetracyanoquinodimethane (TCNQ). TCNQ acts as an efficient mediator for oxidation of the reduced enzyme at 200 mV vs Ag/AgCl. The sensor provides a linear response to glucose over a wide concentration range. The flow injection analysis system has a detection limit of 200 nmol glucose using a 100 .mu.l sample and as been demonstrated to be stable after 800 consecutive sample injections.
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"A Glucose Sensor Utilizing Tetracyanoquinodimethane as a Mediator", S. P. endry and A. P. F. Turner, Horm Metab. Res., (Suppl.) 20, pp. 37-40 (1988) No month available at present time.
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"A New Class of Amperometric Biosensor Incorporating a Polymer Electron-Transfer Mediator", Journal of the American Society, vol. III, 1989 pp. 3482-3484 No month available at present time.
"Graphite Paste-Based Enzymatic Glucose Electrode for Flow Injection Analysis", The Analyst, vol. 113, No. 5, May 1988; Wojciech Matuszeski et al.
"Biocatalytic Oxidation of Glucose on the Conductive Charge Tranfer Complexes", Bioelectrochemistry and Bioenergetics, 8 (1981) pp. 103-113, vol. 128 No month available at present time.
Bell Bruce F.
Gorgos Kathryn
The United States of America as represented by the Secretary of
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