AMPA antagonists and a method of treatment

Details AMPA antagonists and a method of treatment AMPA antagonists and a method of treatment

1997-10-15

1998-12-01

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514215, 540578, 544345, A61K 3155, A61K 31495, C07D48700

Patent

active

058439455

ABSTRACT:
The present patent application discloses compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R.sup.1 is hydrogen, alkyl or benzyl; X is O or NOR.sup.2, wherein R.sup.2 is hydrogen, alkyl or benzyl; Y is N--R.sup.4 wherein R.sup.4 is hydrogen, OH or alkyl; n is 0 or 1; R.sup.6 is phenyl, naphthyl, thienyl, pyridyl, all of which may be substituted one or more times with substituents selected from the group consisting of halogen, CF.sub.3, NO.sub.2, amino, alkyl, alkoxy and phenyl; A is a ring of five to seven atoms fused with the benzo ring at the positions marked a and b. The compounds are useful in the treatment of cerebrovascular disorders. ##STR1##

REFERENCES:
patent: 4912108 (1990-03-01), Jacobsen et al.
patent: 5081123 (1992-01-01), Honore et al.
patent: 5198461 (1993-03-01), Watjen et al.
patent: 5242918 (1993-09-01), Watjen et al.
patent: 5436250 (1995-07-01), Watjen et al.
Cecil et al., Alzheimer's Disease and Related Dementias, Textbook of Medicine, vol. 2, pp. 1992-1996, 1996.
Beal MF; Annals of Neurology, 38 (3) 357-366 (1995) --p. 357.
Lipton SA & Rosenberg PA, The New England Journal of Medicine 330 (9) 613-622 (1994) --p. 613.

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