Amorphous (quinolin-2-ylmethoxy)indole compounds which have usef

Details Amorphous (quinolin-2-ylmethoxy)indole compounds which have usef Amorphous (quinolin-2-ylmethoxy)indole compounds which have usef

1992-11-09

1993-10-19

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546174, C07D40112, A61K 31475

Patent

active

052545679

ABSTRACT:
A form of 3-[N-(p-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-ylmethoxy)indol-2-yl]- 2,2-dimethylpropanoic acid sodium salt, obtained by freeze or spray drying, is more soluble in water than the crystalline form thereof. The compound is useful as an anti-asthmatic, anti-allergic, anti-inflammatory, or cytoprotective agent. It is also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.

REFERENCES:
Suryanarayanan & Mitchell, Inter. J. of Pharm., 24, 1-4 (1985).
Byrn, S. R., Solid State Chem. of Drugs, pp. 10-11, Acad. Press. 1982.
List of Amorphous Pharmaceuticals, Chem. Abst., 1967-1990.

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