Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-07-26
1994-06-14
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546174, C07D40112, A61K 31475
Patent
active
053210336
ABSTRACT:
A form of 3-[N-(p-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-ylmethoxy)indol-2-yl]- 2,2-dimethylpropanoic acid sodium salt, obtained by freeze or spray drying, is more soluble in water than the crystalline form thereof. The compound is useful as an anti-asthmatic, anti-allergic, anti-inflammatory, or cytoprotective agent. It is also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.
REFERENCES:
Suryanarayanan & Mitchell, Inter. J. of Pharm., 24, 1-4 (1985).
Byrn, S. R., Solid State Chem. of Drugs, pp. 10-11, Acad. Press. 1982.
List of Amorphous Pharmaceuticals, Chem. Abst., 1967-1990.
Down Brian
Hutchinson John H.
Davis Zinna N.
Ivy C. Warren
Merck Frosst Canada Inc.
Rose David L.
Yang Mollie M.
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