Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-04-25
1995-11-14
Warden, Jill
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530303, A61K 3828, C07K 1462
Patent
active
054666660
ABSTRACT:
A process for the production of an amorphous monospheric form of insulin derivatives is described, wherein the insulin derivative is dissolved in an n-propanol/buffer mixture at a pH of 4.5 to 6.5, an n-propanol content of more than 13% relative to water is established and the resulting solution is subsequently diluted with water.
REFERENCES:
patent: 5015728 (1991-05-01), Obermeier et al.
Ruegg, V. T., Jarvis, D. Rudinger, J. (1979) Biochem. J. 179, 127-134 "2 Sulfobenzyl a new solubilizing and reversible . . . ".
England, S. and Seifter, S. (1990) Method Enzymol. 182, 285-306 "Precipitation Techniques".
Y. Hu et al., "Crystallographic study on highly stable insulins-crystallization and preliminary crystallographic analysis of A21-Ser mutant," Chemical Abstracts, vol. 118, Nos. 11 (Mar. 1993) p. 97.
J. Markussen et al., "Prolonged-acting insulins, stable in acid solution. Crystallizability and biological potency of insulins substituted in positions A21, B27 and B30," chemical abstracts, vol. 114, No. 25 (Jun. 1991) p. 140.
A. Bialobrzeska et al., "Effect of crystallization parameters on the quality of insulin," chemical abstracts, vol. 97, No. 10 (Sep. 1982) pp. 414-415.
David S. Scott, "CCXI. Crystalline Insulin" Biochemical Journal, vol. XXVIII, No. 4, 1592-1603 (Apr. 1934).
Y. Hu et al., "Crystallographic study on highly stable insulins-crystallization and preliminary crystallographic analysis of A21-Ser mutant," Chemical Abstracts, vol. 118, Nos. 11 (Mar. 1993) p. 97.
J. Markussen et al., "Prolonged-acting insulins, stable in acid solution. crystallizability and biological potency of insulins substituted in positions A21, B27 and B30," chemical abstracts, vol. 114, No. 25 (Jun. 1991) p. 140.
Deil Peter
Geisen Karl
Obermeier Rainer
Sabel Walter
Hoechst Aktiengesellschaft
Prickril Benet
Warden Jill
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