Amorphous hydrate of a cephalosporin antibiotic

Details Amorphous hydrate of a cephalosporin antibiotic Amorphous hydrate of a cephalosporin antibiotic

2007-07-17

2007-07-17

Berch, Mark L. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

10532753

ABSTRACT:
A process for the preparation of cefdinir of the formula (I) the said process comprising the steps of: i) condensing 7-amino-3-cephem-4-carboxylic acid of the formula (XII) wherein R1 is as defined above with compound of the formula (XIII) in the presence of a tertiary amine and an organic solvent, followed by treatment with a base to produce a salt of compound formula (XIV), wherein M+ is a counter ion and ii) hydrolyzing the compound of the formula (XIV) using an acid in the presence of a solvent to produce cefdinir of formula (I).

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Maritza González, II Farmaco, vol. 58, Issue 6, Jun. 2003, pp. 409-418.

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