Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Reexamination Certificate
2005-07-29
2008-12-09
Davis, Ruth A (Department: 1651)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
C435S373000
Reexamination Certificate
active
07462484
ABSTRACT:
Provided are compositions and methods for in vitro generation and in vivo use of tissue for the repair of defective tissue, especially cartilage. Chondrocytes or other cells are cultured in vitro in a biodegradable amorphous carrier within the confines of a space bounded by a semi-permeable membrane with a molecular weight cut-off of greater than 100 kDa. The culture can be subjected to physical/physicochemical conditions that mimic in vivo conditions of the tissue in need of repair or replacement. In one embodiment the invention provides an amorphous preparation of chondrocytes and their extracellular products, suitable for injection.
REFERENCES:
patent: 4846835 (1989-07-01), Grande
patent: 6171610 (2001-01-01), Vacanti et al.
patent: 6242247 (2001-06-01), Mainil-Varlet et al.
patent: 6432713 (2002-08-01), Takagi et al.
patent: 2001/0014473 (2001-08-01), Rieser et al.
patent: 2003/0138873 (2003-07-01), Masuda et al.
patent: 2004/0013712 (2004-01-01), Parma
Mizuno et al., J Cellular Physiology, 2002, 193:319-327.
Bachrach N.M. et al., Changes in proteoglycan synthesis of chondrocytes in articular cartilage are associated with the time-dependent changes in their mechanical environment. J. Biomech. Dec. 1995;28(12):1561-9.
Bachrach N.M. et al., Incompressibility of the solid matrix of articular cartilage under high hydrostatic pressures. J. Biomech. May 1998;31(5):445-51.
Bryant S.J. et al., Controlling the spatial distribution of ECM components in degradable PEG hydrogels for tissue engineering cartilage. J. Biomed Mater Res A. Jan. 1, 2003;64(1):70-9.
Bryant S.J. et al., Hydrogel properties influence ECM production by chondrocytes photoencapsulated in poly(ethylene glycol) hydrogels. J Biomed Mater Res. Jan. 2002;59(1):63-72.
Buschmann M.D. et al., Altered aggrecan synthesis correlates with cell and nucleus structure in statically compressed cartilage. J. Cell Sci. Feb. 1996;109 ( Pt 2):499-508.
Buschmann M.D. et al., Mechanical compression modulates matrix biosynthesis in chondrocyte/agarose culture. J. Cell Sci. Apr. 1995;108 ( Pt 4):1497-508.
Comper W.D. et al., Non-electrostatic factor govern the hydrodynamic properties of articular cartilage proteoglycan. Biochem J. Jan. 15, 1993;289 ( Pt 2):543-7.
Darling EM et al., Articualr cartilage bioreactors and bioprocesses. Tissue Eng. Feb. 2003;9(1):9-26.
Demarteau O et al., Development and validation of a bioreactor for physical stimulation of engineered cartilage. Biorheology. 2003;40(1-3):331-6.
Gray M. et al., Mechanical and physiochemical determinants of the chondrocyte biosynthetic response. J Orthop Res. 1988;6(6):777-92.
Grogan SP et al., A static, closed and scaffold-free bioreactor system that permits chondrogenesis in vitro. Osteoarthritis Cartilage. Jun. 2003;11(6):403-11.
Guilak F. et al., Chondrocyte deformation and local tissue strain in articular cartilage: A confocal microscopy study. J Orthop Res. May 1995; 13(3):410-21.
Guilak F., The deformation behavior and viscoelastic properties of chondrocytes in articular cartilage. Biorheology. 2000;37(1-2):27-44.
Hall A. et al., The effects of hydrostatic pressure on matrix synthesis in articular cartilage. J Orthop Res. Jan. 1991;9(1):1-10.
Kim Y. et al., Mechanical regulation of cartilage biosynthetic behavior: physical stimuli. Arch Biochem Biophys. May 15, 1994;311(1):1-12.
Kim Y.J. et al., The role of cartilage streaming potential, fluid flow and pressure in the stimulation of chondrocyte biosynthesis during dynamic compression. J Biomech. Sep 1995;28(9):1055-66.
Klein-Nulend J. et al., Influence of intermittent compressive force on proteoglycan content in calcifying growth plate cartilage in vitro. J Biol Chem. Nov. 15, 1987;262(32):15490-5.
Lammi M.J. et al., Expression of reduced amounts of structurally altered aggrecan in articular cartilage chondrocytes exposed to high hydrostatic pressure. Biochem J. Dec. 15, 1994; 304 (Pt 3):723-30.
Mainil-Varlet P et al., Articalr cartilage repair using a tissue-engineered cartilage-like implant: an animal study. Osteoarthritis Cartilage. 2001;9 Suppl A:S6-15.
Mankin K.P. et al., Response of physeal cartilage to low-level compression and tension in organ culture. J Pediatr Orthop. Mar.-Apr. 1998;18(2):145-8.
Maroudas A., Biophysical chemistry of cartilaginous tissues with special reference to solute and fluid transport. Biorheology. Jun. 1975;12(3-4):233-48.
Martens PJ et al., Tailoring the degradation of hydrogels formed from multivinyl poly(ethylene glycol) and poly(vinyl alcohol) macromers for cartilage tissue engineering. Biomacromolecules. Mar.-Apr. 2003;4(2):283-92.
Mizuno S. et al., Chondroinduction of human dermal fibroblasts by demineralized bone in three-dimensional culture. Exp Cell Res. Aug. 25, 1996;227(1):89-97.
Mizuno S. et al., Effects of physical stimulation of chondrogenesis in vitro. Mat. Sci. Eng. C. Sep. 3, 1998,6:301-6.
Mow V.C. et al., The extracellular matrix, interstitial fluid and ions as a mechanical signal transducer in articular cartilage. Osteoarthritis Cartilage. Jan. 1999;7(1):41-58.
Mueller S.M. et al., Medium perfusion enhances osteogenesis by murine osteosarcoma cells in three-dimensional collagen sponges. J Bone Miner Res. Dec. 1999;14(12):2118-26.
O'Hara B.P. et al., Influence of cyclic loading on the nutrition of articular cartilage. Ann Rheum Dis. Jul. 1990;49(7):536-9.
Ostendorf R.H. et al., Intermittent loading induces the expression of 3-B-3(-) epitope in cultured bovine articular cartilage. J Rheumatol. Feb. 1994;21(2):287-92.
Palmoski M.J. et al., Effects of static and cyclic compressive loading on articular cartilage plugs in vitro. Arthritis Rheum. Jun. 1984;27(6):675-81.
Parkkinen et al., Effects of cyclic hydrostatic pressure on proteoglycan synthesis in cultured chondrocytes and articular cartilage explants. Arch Biochem Biophys. Jan. 1993;300(1):458-65.
Potter K et al., Cartilage formation in a hollow fiber bioreactor studied by proton magnetic resonance microscopy. Matrix Biol. Nov. 1998;17(7):513-23.
Sah R.L. et al., Biosynthetic response of cartilage explants to dynamic compression. J Orthop Res. 1989;7(5):619-36.
Saini S et al., Concentric cylinder bioreactor for production of tissue engineered cartilage: effect of seeding density and hydrodynamic loading on construct development. Biotechnol Prog. Mar.-Apr. 2003;19(2):510-21.
Torzilli P.A. et al., Characterization of cartilage metabolic response to static and dynamic stress using a mechanical explant test system. J Biomech. Jan. 1997;30(1):1-9.
Davis Ruth A
The Brigham and Women's Hospital, Inc.
Wolf, Greenfield & Sacks, LLP
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