Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1978-11-14
1980-06-24
Peters, G. O.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
423284, C01B 3506, A61K 3318, A61K 3322
Patent
active
042095107
ABSTRACT:
Preparation of the crystalline complex [Na{NH.sub.3.BH.sub.2 -(CN)}.sub.6 from NMe.sub.3.BH.sub.2 I and NaCN in liquid NH.sub.3 is disclosed. Structural details of this novel octahedral complex are obtained by single-crystal X-ray analysis. Evidence indicates that the complex is a valuable antiarthritic agent, since it completely inhibits bacteria-induced chronic arthritis in rats with no evidence of toxic effects. The complex also possesses analgesic and anti-inflammatory activity.
REFERENCES:
patent: 3667923 (1972-06-01), Wade
Bratt, P. J. et al., "J.C.S. Dalton", 1976, pp. 353-356.
Hall Iris H.
Hargrave Karl D.
Mc Phail Andrew T.
Spielvogel Bernard F.
Wisian-Neilson Patty
Bellamy Werten F. W.
Gapcynski William G.
Peters G. O.
The United States of America as represented by the Secretary of
Winters Sherman D.
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