Ammine-alicyclic amine-platinum complexes and antitumor agents

Details Ammine-alicyclic amine-platinum complexes and antitumor agents Ammine-alicyclic amine-platinum complexes and antitumor agents

1987-12-18

1990-02-20

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548402, 548950, 548955, 540465, 540541, A61K 31555, C07D29522

Patent

active

049027972

ABSTRACT:
A compound of the formula (I): ##STR1## (wherein R is C.sub.1 -C.sub.6 alkyl, hydroxy, carboxy, C.sub.1 -C.sub.6 alkoxy, halogen or oxo; m is an integer from 2 to 7; X and Y each is chlorine or nit-rato ligand, or taken together form --OCOCH(R.sup.1)O--, OCOCOO--, ##STR2## R.sup.1 is hydrogen, C.sub.1 -C.sub.5 alkyl, hydroxymethyl, halogmethyl or phenyl; R.sup.2 is hydrogen or C.sub.1 -C.sub.5 alkyl; and n is an integer from 2 to 5), being useful as antitumor agents is provided.

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Schabel, Jr. Pharmac. Ther A., vol. 1, pp. 411-435, (1977).
Braddock, Chem. Abst. 83, 141759e.

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