Aminoxyl-containing radical spin labeling in polymers and copoly

Details Aminoxyl-containing radical spin labeling in polymers and copoly Aminoxyl-containing radical spin labeling in polymers and copoly

1994-08-10

1996-05-14

Dodson, Shelley A.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From carboxylic acid or derivative thereof

528310, 528335, 528354, 528361, 424 111, 424 129, 424 133, 424 181, 424 7808, 424 7814, 424 7827, 424 7829, C08G 7310

Patent

active

055168817

ABSTRACT:
Aminoxyl-containing radical is provided in polymers and copolymers by replacing a hydroxyl moiety in a carboxyl group at a chain end of a starting material biodegradable polymer or copolymer with imino or oxy linked to aminoxyl-containing radical to form an amide linkage or an oxycarbonyl linkage at the chain end of biocompatible polymers or copolymers to the aminoxyl-containing radical. Preferred starting material polymers and copolymers are prepared from the hydroxy alkyl carboxylic acid monomers glycolic acid and lactic acid. Preferred aminoxyl-containing radical is 2,2,6,6-tetramethylpiperidine-1-oxy. Product polymers are useful for aminoxyl-containing radical treatment of tumors, and to increase the efficiency of chemotherapy and ionizing radiation therapy of tumors and for the reconstruction of injured, diseased, or aged human blood vessels.

REFERENCES:
patent: 4999417 (1991-03-01), Domb
Wee, E. L., et al, J. Phys. Chem. 77, 182-189 (1973).
Luoma, G. A., et al, Biochemistry 24, 6591-6598 (1982).
Voronina, S. S., et al, USSR Academy of Science News, 723-730, May 1972.
Bioactive Spin Labels, Zhdanov, R. I., ed., Springer-Verlag, pp. 429-489, New York, 1992.
Snyder, S. H., et al, Scientific American, 68-72, May 1992.
Handbook of Fluorescent Probes and Research Chemicals, 5th edition, by Haugland, R. P.,; K. D. Larison, editor; pp. 1, 2 and 154, Molecular Probes, Inc., Oregon, 1992.
Emmerson, P. T., et al, Nature, 1005-1006, Dec. 5, 1964.
Klimek, M., Nature, 1256-1257, Mar. 19, 1966.
Feldman, P. L., et al, C & EN, 26-38, Dec. 20, 1993.

Affiliated with

Also associated with

Rating

Aminoxyl-containing radical spin labeling in polymers and copoly does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aminoxyl-containing radical spin labeling in polymers and copoly, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aminoxyl-containing radical spin labeling in polymers and copoly will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1896707