Aminothaizoles and their use as adenosine receptor antagonists

Details Aminothaizoles and their use as adenosine receptor antagonists Aminothaizoles and their use as adenosine receptor antagonists

2006-09-19

2006-09-19

Shameem, Golam M. M. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S342000, C514S370000, C544S405000, C546S269700, C546S270700, C548S191000

Reexamination Certificate

active

07109202

ABSTRACT:
Compounds of formula (I) in free or salt form, where A is a C6-C15monovalent aromatic group. R1is hydrogen, phenyl optionally substituted by one or more substituents selected from halogen, cyano, hydroxy, C1–C8-alkyl, C1–C8-haloalkyl, C1–C8-alkoxy, C1–C8-alkoxy-C1–C8-alkyl or acyloxy, or a 5- or 6-membered monovalent heterocyclic group, R2is hydrogen, C1-C8-alkyl, acyl or CON(R3)R4, provided that R2is C1–C8-alkyl, acyl or CON(R3)R4when R1is hydrogen, R3and R4are each independently hydrogen, or C1–C8-alkyl, together with the nitrogen atom to which they are attached denote a 5- or 6-membered heterocyclic group, and Zl, Z2, Z3and Z4are each independently N or CR5, at least one of them being CR5, and R5is hydrogen, C1–C8-alkyl or C1–C8-alkoxy. The compounds are useful as adenosine receptor antagonists, particularly in the treatment of inflammatory or obstrucive airways diseases

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