Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-10-05
1999-07-06
Powers, Fiona T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514371, 514381, 514383, 514398, 514407, 544322, 5482628, 548195, 5483325, 5483717, A61K 3141, A61K 31415, C07D25706, C07D23140
Patent
active
059197870
ABSTRACT:
The current invention discloses aminotetrazole derivatives useful as nitric oxide synthase inhibitors.
REFERENCES:
patent: 4713369 (1987-12-01), Stiiber
patent: 5059712 (1991-10-01), Griffith
patent: 5081148 (1992-01-01), Braquet et al.
patent: 5132453 (1992-07-01), Griffith
patent: 5196450 (1993-03-01), Sjoerdsma et al.
patent: 5273875 (1993-12-01), Griffith
patent: 5281627 (1994-01-01), Griffith
patent: 5362744 (1994-11-01), Purchase, Jr. et al.
patent: 5364881 (1994-11-01), Griffith et al.
patent: 5464858 (1995-11-01), Griffith et al.
Gould et al., "Nucleoside Intermediates in Blasticidin S Biosynthesis Identified by the In Vivo Use of Enzyme Inhibitors", Can. J. Chem., vol. 72, pp. 6-11, 1994.
Tsunematsu et al., ".beta.-Naphthylamides of Guanidinophenyl Amino Acids as Substrates of Aminopeptidases", Chem. Pharm. Bull., vol. 36, No. 3, pp. 1205-1209, 1988.
Funabashi et al., "A New Anti-MRSA Dipeptide, TAN-1057 A", Tetrahedron, vol. 49, No. 1, pp. 13-28, 1993.
Prabhakaran et al., "Studies on Nitrogen Metabolism Using .sup.13 C NMR Spectroscopy.5..sup.1 Metabolism of L-.alpha.-Arginine in the Biosynthesis of Blasticidin S", Tetrahedron, vol. 27, No. 33, pp. 3815-3818, 1986.
Palacios, et al., "Nitric Oxide from L-Arginine Stimulates the Soluble Guanylate Cyclase in Adrenal Glands", Biochemical and Biophysical Research Communications, vol. 165, No. 2, pp. 802-809, 1989.
Knowles et al., "Kinetic Characteristics of Nitric Oxide Synthase from Rat Brain", Biochem. J., vol. 269, pp. 207-210, 1990.
Chemical Abstracts, 107:40336y, 1987.
Chemical Abstracts, 63:5641d, 1965.
Chemical Abstracts, 97:38442m, 1982.
Chemical Abstracts, 76:43768t, 1972.
Chemical Abstracts, 118:72838g, 1993.
Chemical Abstracts, 64:17593h, 1966.
Chemical Abstracts, 115:29868t, 1991.
Chemical Abstracts, 104:202858, 1986.
Stuehr et al., "Mammalian Nitric Oxide Synthases" 287-347.
Plapp et al., Analytical Biochem 62:291-294 (1974).
Proudfoot et al., J. Biol Chem 264 No. 15:8764-8770 (1989).
D.D. Rees, Br. J. Pharmacol. 101 No. 3:746-752 (1990).
Plapp et al., Anal. Biochem 62 No. 1:291-294 (1974).
Hallinan E. Ann
Hansen, Jr. Donald W.
Tsymbalov Sofya
Bennett Dennis A.
G. D. Searle & Co.
Powers Fiona T.
Scrivner Alan L.
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