Aminotetralols

Details Aminotetralols Aminotetralols

1975-06-12

1977-07-12

Torrence, Dolph H.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260327R, 260335, 2603459, 2603477, 260456A, 260457, 260463, 260476C, 260479C, 260479R, 260479S, 260486R, 260487, 260488C, 260488D, 26050118, 26050119, 2605705P, 2605707, 2605708R, 2605709, 260573, 260574, 260575, 260934, 424275, 424283, 424285, 424303, 424308, 424311, 424316, A61K 3113, A61K 31205, A61K 3124, C07C 9142

Patent

active

040355128

ABSTRACT:
Novel aminotetralol compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, acyl derived from carboxylic acid, or a hydrocarbon group which may be substituted; --OZ.sup.1 is hydroxyl which may be protected; Y is hydrogen, acyl, hydroxyl which may be protected, amino which may be substituted, nitro, cyano or halogen; and n is zero, 1 or 2 with a proviso that when Y is hydrogen or hydroxyl which may be protected, n is not zero, and their salts, have excellent pharmacological activities such as strong bronchodilating activity. They are useful as medicines, for example, for treatment of asthma.

REFERENCES:
patent: 2549684 (1951-04-01), Heinzelmann
patent: 3458577 (1969-07-01), Galantay
patent: 3930022 (1975-12-01), Hauck et al.
Chiemprasert et al., Ann. Chem., Band 685, pp. 141-148 (1965).

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