Aminotetralin derivative for the therapy of cardiovascular disea

Details Aminotetralin derivative for the therapy of cardiovascular disea Aminotetralin derivative for the therapy of cardiovascular disea

1999-06-09

2000-08-15

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514657, A61K 3121, A61K 31135

Patent

active

061037605

ABSTRACT:
Left ventricular dysfunction is treated by a process, comprising:
administering to a subject suffering from left ventricular remodeling a therapeutically effective amount of 5,6-dihydroxy-2-methylaminotetralin, or 5,6-diisobutyroyl-oxy-2-methyl-aminotetralin, or a pharmaceutically acceptable salt thereof in combination with an angiotensin-converting enzyme inhibitor.

REFERENCES:
patent: 4134997 (1979-01-01), Cannon et al.
Carine Morisoco et al, "Hemodynamic Effects of Graded Oral Doses of a New Dopaminergic Analogue CHF 1035 in Patients with Congestive Heart Failure", Special Issue, Journal of the American College of Cardiology, Feb. 1995.
Enrico Redenti et al, Application of .gamma.-Cyclodextrin to Enantiomeric Purity Determination of a New 2-Amino-Tetralin Derivative .gamma. .sup.1 H-NMR Spectroscopy, Chirality 4:404-405 (1992).

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