Aminosulfonyl urea ACAT inhibitors

Details Aminosulfonyl urea ACAT inhibitors Aminosulfonyl urea ACAT inhibitors

1991-08-19

1993-05-25

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

5142312, 5142378, 5142382, 514247, 514255, 514256, 514307, 514311, 514315, 514357, 514359, 514365, 514373, 514378, 514381, 514383, 514406, 514416, 514419, 514424, 514427, 514438, 514443, 514461, 514469, 514481, 514593, 514824, A61K 31175, C07C31100

Patent

active

052142060

ABSTRACT:
The present invention provides pharmaceutically useful compounds which are aminosulfonyl urea compounds which are ACAT inhibitors rendering them useful in controlling blood cholesterol levels, pharmaceutical compositions and methods of using the ACAT inhibitors and closely related compounds which are also aminosulfonyl urea compounds.

REFERENCES:
patent: 2312404 (1943-03-01), Haack
patent: 3242174 (1966-03-01), McManus et al.
patent: 4515620 (1985-05-01), Bohner
J. Med. Chem. 8, 766-776 (1965), J. M. McManus et al., "Sulfamylurea Hypoglycemic Agents. I. Synthesis and Screening".
J. Med. Chem. 8, 777-781 (1965), Edward H. Wiseman et al., "Sulfamylurea Hypoglycemic Agents. II. Drug Dynamic Studies".
J. Med. Chem. 8, 781-784 (1965), J. W. McFarland et al, "Sulfamylurea Hypoglycemic Agents. III. Tetrasubstituted Sulfamylureas and N-Sulfamylcarbamates".
Ann. 562, 214 (1949), S. Peterson, "Uber neue Reaktionen von Sulfamiden".

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