Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1993-06-10
1994-08-09
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514600, 514603, A61K 3118
Patent
active
053366905
ABSTRACT:
A compound of the following general formula which is useful in treating hypercholesterolemia and atherosclerosis: ##STR1## wherein X is oxygen or sulfur; R is hydrogen, alkyl having from 1 to 8 carbon atoms, or benzyl; R.sub.1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, an aralkyl group, a heterocyclic group, or a hydrocarbon chain of from 1 to 20 carbon atoms which is saturated or contains 1 to 3 double bonds and each of R.sub.2 and R.sub.3 is selected from hydrogen, provided both are not hydrogen, an aralkyl group, a hydrocarbon chain of from 1 to 20 carbon atoms which is saturated or contains 1 to 3 double bonds, an w-substituted alkylC.sub.1-6, a heterocyclic group, phenyl, substituted phenyl or NR.sub.2 R.sub.3 taken together form a monocyclic heterocyclic group.
REFERENCES:
patent: 4627889 (1986-12-01), Bernheim et al.
Phosphorus and Sulfur, 1984, vol. 19, pp. 167-172; M. Hedayatullah, et al.
Chem. Ber., 1963, 96, pp. 56-67; R. Graf.
J. Med. Chem., 1965, 8, pp. 781-784; J. McFarland, et al.
Tetrahedron Letters, 1983, vol. 24, No. 30, pp. 3091-3094; J.-L. Montero, et al.
Picard Joseph A.
Sliskovic Drago R.
Ashbrook Charles W.
Atkins Michael J.
Cintins Marianne M.
Criares T. J.
Warner-Lambert & Company
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