Aminosulfonyl carbamates

Details Aminosulfonyl carbamates Aminosulfonyl carbamates

1991-08-19

1993-10-19

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

544159, 544283, 546233, 548491, 548542, 558233, 560134, 560137, 560148, C07C30706

Patent

active

052547159

ABSTRACT:
A compound of the following general formula which is useful in treating hypocholesterolemia and atherosclerosis: ##STR1## wherein X is oxygen or sulfur; R is hydrogen, alkyl having from 1 to 8 carbon atoms, or benzyl; R.sub.1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, an aralkyl group, a heterocyclic group, or a hydrocarbon chain of from 1 to 20 carbon atoms which is saturated or contains 1 to 3 double bonds and each of R.sub.2 and R.sub.3 is selected from hydrogen, provided both are not hydrogen, an aralkyl group, a hydrocarbon chain of from 1 to 20 carbon atoms which is saturated or contains 1 to 3 double bonds, an w-substituted alkylC.sub.1-6, a heterocyclic group, phenyl, substituted phenyl or NR.sub.2 R.sub.3 taken together form a monocyclic heterocyclic group.

REFERENCES:
Phosphorus and Sulfur 19(2), 167-172 (1984), M. Hedayatullah "Syntheses a l'aide d'Heterocumulenes".
Chem. Ber. 96, 56-67 (1963), R. Graf, "Reactions with N-carbonylsulfamic acid chloride [1], II [2]L: Alcohols and phenols",
J. Med. Chem. 8, 781-784 (1965), J. McFarland, "Sulfamylurea Hypoglycemic Agents. III. Tetrasubstituted Sulfamylureas and N-Sulfamylcarbamates".
Tetrahedron Letters 24, (30) 3091-3094 (1983), J. Montero, "Selective Synthesis of Sulfonylureas and Carboxysulfamides a Novel Route to Oxazolidinones".

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