(Aminostyryl)pyridinium compounds for radiolabelling cell membra

Details (Aminostyryl)pyridinium compounds for radiolabelling cell membra (Aminostyryl)pyridinium compounds for radiolabelling cell membra

1996-06-27

1998-11-24

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Radioactive metal containing

534 14, 424 165, 424 185, 546329, 546334, C09F 1300, C07D21170, A61K 5104

Patent

active

058408592

ABSTRACT:
A compound is provided of formula I: ##STR1## wherein n is 4-16, Det is an organic group comprising a radioisotope or capable of chelating a radioisotope, and Z.sup.- is one equivalent of a biologically acceptable anion, which compounds are useful to radiolabel cellular membranes, as of hematopoietic cells.

REFERENCES:
patent: 4342739 (1982-08-01), Kakimi et al.
patent: 4544546 (1985-10-01), Wang et al.
patent: 4560665 (1985-12-01), Nakae et al.
patent: 4636479 (1987-01-01), Martin et al.
patent: 4698263 (1987-10-01), Wagner et al.
patent: 4707453 (1987-11-01), Wagner et al.
patent: 5021571 (1991-06-01), Mease et al.
patent: 5089663 (1992-02-01), Mease et al.
patent: 5292938 (1994-03-01), Mease et al.
patent: 5334729 (1994-08-01), Mease et al.
patent: 5369036 (1994-11-01), Mercolino et al.
patent: 5385822 (1995-01-01), Melnicoff et al.
Lambert et al., Nucl. Med. Biol., vol. 23(4), pp. 417-427, May 1996.
J. P. Corsetti, et al. "The Labeling of Lipoproteins for Studies of Cellular Binding with a Fluorescent Lipophilic Dye." Anal.Biochem. 195, pp. 122-128, (15 May 1991).
Otto A. Gansow. "Newer Approaches to the Radiolabeling of Monoclonal Antibodies by Use of Metal Chelates." Nucl.Med.Biol., vol. 18, No. 4, pp. 369-381, (1991).
A. Hassner, et al. "Charge-Shift Probes of Membrane Potential. Synthesis", J. Org. Chem., vol. 49, pp. 2546-2551, (1984).
E. Lannto. "Investigation of Suspected Intra-abdominal Sepsis: The Contribution of Nuclear Medicine." Scandinavian Journal of Gastroenterology, vol. 29,Suppl. 203, pp. 11-14, (1994).
Leslie M. Loew, et al. "Charge-Shift Probes of Membrane Potential." Biophysical Journal, vol.34, No.3, pp. 353-365, (Jun. 1981).
L. M. Loew, et al. "Charge-Shift Probes of Membrane Potential Characterisation of Aminostyrylpyridinium Dyes of the Squid Giant Axon." Chemical Abstracts, 102, Abstract No. 128162w, p. 295, (1985).
J. G. McAfee, et al. ".sup.99m Tc-HM-PAO for Leukocyte Labeling--Experimental Comparison with .sup.111 In Oxine in Dogs." Eur.J.Nucl.Med.,, vol.13, No.7, pp. 353-357, (1987).
A. M. Peters, et al. "Imaging Inflammation: Current Role of Labeled Autologous Leukocytes" J. Nucl. Med., vol. 33, No. 1, pp. 65-67, (Jan. 1992).
S. H. Saverymuttu, et al. "Quantitative Fecal Indium 111-Labeled Leukocyte Excretion in the Assessment of Disease in Crohn's Disease." Gastroent., vol.85, No.6, pp. 1333-1339, (1983).
Suresh C. Srivastava, et al. "Progress in Research in Ligands, Nuclides and Techniques for Labeling Monoclonal Antibodies." Nuclear Medicine and Biology, vol.18, No.6, pp. 589-603, (1991).

Affiliated with

Also associated with

Rating

(Aminostyryl)pyridinium compounds for radiolabelling cell membra does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with (Aminostyryl)pyridinium compounds for radiolabelling cell membra, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and (Aminostyryl)pyridinium compounds for radiolabelling cell membra will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1703576