Organic compounds -- part of the class 532-570 series – Organic compounds – Cyclopentanohydrophenanthrene ring system containing
Patent
1995-06-07
1998-11-24
Geist, Gary
Organic compounds -- part of the class 532-570 series
Organic compounds
Cyclopentanohydrophenanthrene ring system containing
558 29, C07C30512, C07J 4100
Patent
active
058409360
ABSTRACT:
Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.
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Kinney William
Rao Meena
Shinnar Ann
Zasloff Michael
Frazier Barbara S.
Geist Gary
Magainin Pharmaceuticals Inc.
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