Drug – bio-affecting and body treating compositions – Topical body preparation containing solid synthetic organic... – Ophthalmic preparation
Patent
1992-02-19
1993-10-12
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Topical body preparation containing solid synthetic organic...
Ophthalmic preparation
424427, 424428, 424450, 424451, 424464, 514169, 514170, 514172, 514176, 514177, 514178, 514179, 514180, 514182, 514774, 514777, 514781, 514784, 514785, 514801, 514912, 514913, 514914, 514944, A61K 4728, A61K 3158, A61K 3722
Patent
active
052523195
ABSTRACT:
Methods and compositions for preventing or treating ophthalmic diseases or disorders wherein an ophthalmically effective amount of the C.sub.20 through C.sub.26 aminosteroids of formula XI and their pharmaceutical, acceptable salts, hydrates or solvates is administered in an inert vehicle to arrest oxidation processes damaging to the eye.
REFERENCES:
patent: 5099019 (1992-03-01), McCall et al.
patent: 5120843 (1992-06-01), McCall et al.
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"Inhibition of Carbon Tetrachloride-Induced Lipid Peroxidation in Rat Hepatic Microsomes-Dissociation from Hepatoprotective Effects In Vivo" T. W. Petry et al, Abstracts of the 4th Intn'l Symposium on Biological Reactive Intermediates, Jan. 14-17, 1990, Hosted by the Center for Toxicology, The University of Arizona, Tucson, Ariz.
"Effects of the Antioxidants U74006F, U78517G and N,N'-Diphenyl-p-phenylenediamine on Carbon Tetrachloride-Induced Toxicity in Precision-Cut Rat Liver Slices," G. H. I. Wolfgang et al, Abstracts of the 4th Intn'l Symposium on Biological Reactive Intermediates, Jan. 14-17, 1990 Hosted by The Center for Toxicology, The University of Arizona, Tucson, Ariz.
"Modulation of Diquat-Induced Toxicity In Vitro by Novel Inhibitors of Lipid Peroxidation and the Antioxidant Diphenyl-p-phenylenediamine," R. A. Jolly et al, The Toxicologist, Abstracts of the 29th Annual Meeting, vol. 10, No. 1, Feb. 1990.
"Inhibition of Diquant-Induced Lipid Peroxidation and Toxicity In Vitro by Novel Antioxidants," G. H. I. Wolfgang et al, The Toxicologist, Abstracts of the 29th Annual Meeting, vol. 10, No. 1, Feb. 1990.
Babcock John C.
Bowman Lyle M.
Chandrasekaran Santosh K.
Polansky Jon R.
Si Erwin C.-C.
Azpuru Carlos
InSite Vision Incorporated
Page Thurman K.
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